Figure 1.

Pathways of the involvement of miR-21 in carcinogenesis. miR, microRNA; pri-mRNA, primary mRNA; pre-mRNA, precursor mRNA; AP-1, activated protein-1; NFI, nuclear factor I; Maspin, mammary serine protease inhibitor; Fas-L, Fas ligand; Spry 1/2, sprouty homolog 1/2; PDCD4, programmed cell death protein 4; TPM1, tropomyosin 1; RECK, reversion-induced cystine-rich protein with Kazal motifs; TIMP3, tissue inhibitor of metalloproteinases 3; ANP32A, acidic nuclear phosphoprotein 32 family, member A; MMP, matrix metalloproteinase; PTEN, phosphatase and tensin homologue deleted on chromosome 10; STAT3, signal transducer and activator of transcription 3; JNK, c-Jun N-terminal kinase; MDR, multi-drug resistance; ERK, extracellular signal-regulated kinase; MAPK, mitogen-associated protein kinase.