Table II.
Frequencies of methylation in lung cancer and corresponding non-malignant lung tissues from the same patients.
| Bronchus tissue | Lung tissue | Tumor tissue | ||||
|---|---|---|---|---|---|---|
| Analyzed gene | % patients | n/ntotal | % patients | n/ntotal | % patients | n/ntotal |
| MGMT | 7.1 | 2/28 | 2.4 | 1/42 | 7.1 | 3/42 |
| RASSF1A | 3.4 | 1/29 | 0.0 | 0/42 | 26.2 | 11/42 |
| RASAL1 | 0.0 | 0/27 | 2.4 | 1/42 | 4.8 | 2/42 |
| PDCD4 | 0.0 | 0/27 | 0.0 | 0/42 | 0.0 | 0/42 |
| MTSS1 | 0.0 | 0/24 | 0.0 | 0/42 | 0.0 | 0/42 |
| TUSC3 | 67.9 | 19/28 | 31.0 | 13/42 | 59.5 | 25/42 |
MGMT, O-6-methylguanine-DNA methyltransferase; RASSF1A, Ras association domain family member 1A; RASAL1, Ras protein activator like 1; PDCD4, programmed cell death 4; MTSS1, metastasis suppressor 1; TUSC3, tumor suppressor candidate 3.