(A) MMP-13 protein expression in cultured supernatant by enzyme-linked immunosorbent assay. *P<0.05 vs. control; #P<0.05, ##P<0.01 vs. IL-1β-stimulated cells. (B) Western blotting analysis of MMP-13 protein expression levels in IL-1β-induced SW1353 cells, normalized to β-actin. Data are expressed as the mean ± standard deviation.**P<0.05 vs. control; #P<0.05, ##P<0.01 vs. IL-1β-stimulated cells. **P<0.05 vs. control; #P<0.05, ##P<0.01 vs. IL-1β-stimulated cells. MMP, matrix metalloproteinase; OPG, osteoprotegerin; IL-1β, interleukin-1β.