Table III.
Allele frequency of LRP5 single-nucleotide polymorphisms in non-small cell lung cancer patients and healthy controls.
| Gene allele | NSCLC n (%) | Controls n (%) | P-value | OR (95% CI) | Male cases n (%) | Male cases n (%) | P-value | OR (95% CI) | Female cases n (%) | Female controls n (%) | P-value | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rs4930573 | 0.27 | 1.14 (0.91–1.43) | 0.57 | 1.09 (0.81–1.46) | 0.35 | 1.19 (0.81–1.73) | ||||||
| C | 827 (82.7) | 808 (80.8) | 579 (82.7) | 422 (81.5) | 248 (82.7) | 384 (80.0) | ||||||
| G | 173 (17.3) | 192 (19.2) | 121 (17.3) | 96 (18.5) | 52 (17.3) | 96 (20.0) | ||||||
| Rs312009 | 0.96 | 0.99 (90.81–1.22) | 0.92 | 1.01 (0.78–1.32) | 0.68 | 0.93 (0.66–1.31) | ||||||
| T | 244 (24.4) | 245 (24.5) | 176 (25.1) | 129 (24.9) | 68 (22.7) | 115 (24.0) | ||||||
| G | 756 (75.6) | 755 (75.5) | 524 (74.9) | 389 (75.1) | 232 (77.3) | 365 (76.0) | ||||||
| Rs312014 | 0.23 | 1.12 (0.94–1.33) | 0.23 | 1.15 (0.92–1.44) | 0.72 | 1.06 (0.79–1.41) | ||||||
| C | 557 (55.7) | 530 (53.0) | 393 (56.1) | 273 (52.7) | 164 (54.7) | 256 (53.3) | ||||||
| G | 443 (44.3) | 470 (47.0) | 307 (43.9) | 245 (47.3) | 136 (45.3) | 224 (46.7) | ||||||
| Rs3781590 | 1.00 | 1.00 (0.75–1.34) | 0.21 | 1.29 (0.86–1.94) | 0.36 | 0.81 (0.51–1.28) | ||||||
| T | 101 (10.1) | 101 (10.1) | 70 (10.0) | 41 (7.9) | 31 (10.3) | 60 (12.5) | ||||||
| C | 899 (89.9) | 899 (89.9) | 630 (90.0) | 477 (92.1) | 269 (89.7) | 420 (87.5) | ||||||
| Rs312015 | 0.96 | 0.99 (0.83–1.19) | 0.92 | 1.01 (0.80–1.28) | 0.88 | 0.98 (0.73–1.31) | ||||||
| C | 398 (39.8) | 399 (39.9) | 279 (39.9) | 205 (39.6) | 119 (39.7) | 193 (40.2) | ||||||
| G | 602 (60.2) | 601 (60.1) | 421 (60.1) | 313 (60.4) | 181 (60.3) | 287 (59.8) | ||||||
| Rs491347 | 0.40 | 1.10 (0.88–1.37) | 0.14 | 1.23 (0.93–1.62) | 0.86 | 1.04 (0.71–1.52) | ||||||
| T | 810 (81.0) | 795 (79.5) | 561 (80.1) | 397 (76.6) | 249 (83.0) | 396 (82.5) | ||||||
| C | 190 (19.0) | 205 (20.5) | 139 (19.9) | 121 (23.4) | 51 (17.0) | 84 (17.5) | ||||||
| Rs1784235 | 0.37 | 1.11 (0.89–1.38) | 0.09 | 1.26 (0.96–1.67) | 0.99 | 0.99 (0.68–1.46) | ||||||
| T | 812 (81.2) | 796 (79.6) | 564 (80.6) | 397 (76.6) | 248 (82.7) | 397 (82.7) | ||||||
| C | 188 (18.8) | 204 (20.4) | 136 (19.4) | 121 (23.4) | 52 (17.3) | 83 (17.3) | ||||||
| Rs648438 | 0.38 | 1.13 (0.85–1.51) | 0.18 | 1.30 (0.89–1.89) | 0.52 | 0.87 (0.56–1.34) | ||||||
| T | 899 (89.9) | 887 (88.7) | 638 (91.1) | 460 (88.8) | 261 (87.0) | 425 (88.5) | ||||||
| C | 101 (10.1) | 113 (11.3) | 62 (8.9) | 58 (11.2) | 39 (13.0) | 55 (11.5) | ||||||
| Rs3736228 | 0.16 | 0.85 (0.69–1.07) | 0.18 | 1.30 (0.89–1.89) | 0.93 | 0.98 (0.67–1.43) | ||||||
| T | 185 (18.5) | 210 (21.0) | 132 (18.9) | 124 (23.9) | 53 (17.7) | 86 (17.9) | ||||||
| C | 815 (81.5) | 790 (79.0) | 568 (81.1) | 394 (76.1) | 247 (82.3) | 394 (82.1) | ||||||
| Rs624947 | 0.79 | 1.03 (0.80–1.33) | 0.25 | 0.82 (0.58–1.15) | 0.17 | 1.34 (0.89–2.02) | ||||||
| A | 863 (86.3) | 859 (85.9) | 602 (86.0) | 457 (88.2) | 261 (87.0) | 400 (83.3) | ||||||
| G | 137 (13.7) | 141 (14.1) | 98 (14.0) | 61 (11.8) | 39 (13.0) | 80 (16.7) | ||||||
| Rs607887 | 0.27 | 0.89 (0.72–1.09) | 0.08 | 0.79 (0.61–1.03) | 0.99 | 1.00 (0.71–1.42) | ||||||
| T | 227 (22.7) | 248 (24.8) | 160 (22.9) | 141 (27.2) | 67 (22.3) | 107 (22.3) | ||||||
| C | 773 (77.3) | 752 (75.2) | 540 (77.1) | 377 (72.8) | 233 (77.7) | 373 (77.7) |
LRP5, low-density lipoprotein receptor-related protein 5; NSCLC, non-small cell lung cancer; OR, odds ratio; CI, confidence interval.