Table IV.
Genotypes of LRP5 single-nucleotide polymorphisms in non-small cell lung cancer patients and controls.
| Genotype | NSCLC n=500 (%) | Controls n=500 (%) | P-value | OR (95% CI) | Male NSCLCs n=350 (%) | Male controls n=259 (%) | P-value | OR (95% CI) | Female NSCLCs n=150 (%) | Female controls n=240 (%) | P-value | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rs4930573 | ||||||||||||
| CC | 339 (67.8) | 324 (64.8) | 1 (Reference) | 236 (67.4) | 169 (65.3) | 1 (Reference) | 103 (68.7) | 154 (64.2) | 1 (Reference) | |||
| GG | 12 (2.4) | 16 (3.2) | – | 7 (2.0) | 6 (2.3) | – | 5 (3.3) | 10 (4.2) | – | |||
| CG | 149 (29.8) | 160 (32.0) | 0.52 | – | 107 (30.6) | 84 (32.4) | 0.84 | – | 42 (28.0) | 76 (31.7) | 0.65 | – |
| CG+GG | 161 (32.2) | 176 (35.2) | 0.32 | 0.87 (0.67–1.14) | 114 (32.6) | 90 (34.7) | 0.53 | 0.91 (0.65–1.27) | 47 (31.3) | 86 (35.8) | 0.36 | 0.82 (0.53–1.26) |
| Rs312009 | ||||||||||||
| CC | 288 (57.6) | 291 (58.2) | 1 (Reference) | 198 (56.6) | 145 (56.0) | 1 (Reference) | 90 (60.0) | 146 (60.8) | 1 (Reference) | |||
| TT | 32 (6.4) | 36 (7.2) | – | 24 (6.9) | 15 (5.8) | – | 8 (5.3) | 21 (8.7) | – | |||
| CT | 180 (36.0) | 173 (34.6) | 0.82 | – | 128 (36.5) | 99 (38.2) | 0.83 | – | 52 (34.7) | 73 (30.5) | 0.37 | – |
| TT+CT | 212 (42.4) | 209 (41.8) | 0.85 | 0.98 (0.76–1.25) | 152 (43.4) | 114 (44.0) | 0.89 | 1.02 (0.74–1.42) | 60 (40.0) | 94 (39.2) | 0.36 | 0.82 (0.53–1.26) |
| Rs312014 | ||||||||||||
| CC | 157 (31.4) | 145 (29.0) | 1 (Reference) | 115 (32.9) | 74 (28.6) | 1 (Reference) | 42 (28.0) | 71 (29.6) | 1 (Reference) | |||
| CG | 243 (48.6) | 240 (48.0) | – | 163 (46.6) | 125 (48.2) | – | 80 (53.3) | 114 (47.5) | – | |||
| GG | 100 (20.0) | 115 (23.0) | 0.46 | – | 72 (20.5) | 60 (23.2) | 0.49 | – | 28 (18.7) | 55 (22.9) | 0.47 | – |
| GG+CG | 343 (68.6) | 355 (71.0) | 0.41 | 1.12 (0.86–1.47) | 235 (67.1) | 185 (71.4) | 0.26 | 1.22 (0.86–1.74) | 108 (72.0) | 169 (70.4) | 0.74 | 0.93 (0.59–1.45) |
| Rs3781590 | ||||||||||||
| CC | 400 (80.0) | 402 (80.4) | 1 (Reference) | 281 (80.3) | 218 (84.2) | 1 (Reference) | 119 (79.3) | 183 (76.2) | 1 (Reference) | |||
| TT | 1 (0.2) | 3 (0.6) | – | 1 (0.3) | 0 (0.0) | – | 0 (0.0) | 3 (1.3) | – | |||
| CT | 99 (19.8) | 95 (19.0) | 0.58 | – | 68 (19.4) | 41 (15.8) | 0.35 | – | 31 (20.7) | 54 (22.5) | 0.34 | – |
| TT+CT | 100 (20.0) | 98 (19.6) | 0.87 | 0.98 (0.71–1.33) | 69 (19.7) | 41 (15.8) | 0.22 | 0.77 (0.50–1.17) | 31 (20.7) | 57 (23.8) | 0.48 | 1.20 (0.73–1.96) |
| Rsa312015 | ||||||||||||
| GG | 184 (36.8) | 181 (36.2) | 1 (Reference) | 132 (37.7) | 94 (36.3) | 1 (Reference) | 52 (34.7) | 87 (36.2) | 1 (Reference) | |||
| CG | 234 (46.8) | 239 (47.8) | – | 157 (44.9) | 125 (48.3) | – | 77 (51.3) | 113 (47.1) | – | |||
| CC | 82 (16.4) | 80 (16.0) | 0.95 | – | 61 (17.4) | 40 (15.4) | 0.67 | – | 21 (14.0) | 40 (16.7) | 0.66 | – |
| CC+CG | 316 (63.2) | 319 (63.8) | 0.84 | 1.03 (0.79–1.33) | 218 (62.3) | 165 (63.7) | 0.72 | 1.06 (0.76–1.48) | 98 (65.3) | 153 (63.7) | 0.75 | 0.93 (0.64–1.50) |
| Rs491347 | ||||||||||||
| TT | 327 (65.4) | 311 (62.2) | 1 (Reference) | 221 (63.1) | 149 (57.5) | 1 (Reference) | 106 (70.7) | 161 (67.1) | 1 (Reference) | |||
| CC | 17 (3.4) | 16 (3.2) | – | 10 (2.9) | 11 (4.2) | – | 7 (4.6) | 5 (2.1) | – | |||
| CT | 156 (31.2) | 173 (34.6) | 0.52 | – | 119 (034.0) | 99 (38.2) | 0.31 | – | 37 (24.7) | 74 (30.8) | 0.18 | – |
| CC+CT | 173 (34.6) | 189 (37.8) | 0.29 | 1.15 (0.89–1.49) | 129 (36.9) | 110 (42.5) | 0.16 | 1.27 (0.91–1.76) | 44 (0.293) | 79 (32.9) | 0.46 | 1.18 (0.77–1.85) |
| Rs1784235 | ||||||||||||
| TT | 329 (65.8) | 312 (62.4) | 1 (Reference) | 224 (64.0) | 149 (57.5) | 1 (Reference) | 105 (70.0) | 162 (67.5) | 1 (Reference) | |||
| CC | 17 (3.4) | 16 (3.2) | – | 10 (2.9) | 11 (4.2) | – | 7 (4.7) | 5 (2.1) | – | |||
| CT | 154 (30.8) | 172 (34.4) | 0.48 | – | 116 (33.1) | 99 (38.2) | 0.23 | – | 38 (25.3) | 73 (30.4) | 0.23 | – |
| CC+CT | 171 (34.2) | 188 (37.6) | 0.26 | 1.16 (0.90–1.50) | 126 (36.0) | 110 (42.5) | 0.11 | 1.31 (0.94–1.82) | 45 (30.0) | 78 (32.5) | 0.61 | 1.12 (0.72–1.75) |
| Rs648438 | ||||||||||||
| TT | 407 (81.4) | 395 (79.0) | 1 (Reference) | 293 (83.7) | 205 (79.2) | 1 (Reference) | 114 (76.0) | 189 (78.7) | 1 (Reference) | |||
| CC | 8 (1.6) | 8 (1.6) | – | 5 (1.4) | 4 (1.5) | – | 3 (2.0) | 4 (1.7) | – | |||
| CT | 85 (17.0) | 97 (19.4) | 0.62 | – | 52 (14.9) | 50 (19.3) | 0.34 | – | 33 (22.0) | 47 (19.6) | 0.81 | – |
| CC+CT | 93 (18.6) | 105 (21.0) | 0.34 | 1.16 (0.85–1.59) | 57 (16.3) | 54 (20.8) | 0.15 | 1.35 (0.90–2.06) | 36 (24.0) | 51 (21.3) | 0.53 | 0.85 (0.53–1.39) |
| Rs3736228 | ||||||||||||
| CC | 332 (66.4) | 306 (61.2) | 1 (Reference) | 227 (64.9) | 146 (56.4) | 1 (Reference) | 105 (70.0) | 159 (66.2) | 1 (Reference) | |||
| TT | 17 (3.4) | 16 (3.2) | – | 9 (2.6) | 11 (4.2) | – | 8 (5.3) | 5 (2.1) | – | |||
| CT | 151 (30.2) | 178 (35.6) | 0.19 | – | 114 (32.6) | 102 (39.4) | 0.08 | – | 37 (24.7) | 76 (31.7) | 0.10 | – |
| TT+CT | 168 (33.6) | 194 (38.8) | 0.09 | 1.25 (0.97–1.62) | 123 (35.1) | 113 (43.6) | 0.03 | 1.43 (0.03–1.99) | 45 (30.0) | 81 (33.8) | 0.44 | 1.19 (0.77–1.85) |
| Rs624947 | ||||||||||||
| AA | 367 (73.4) | 368 (73.6) | 1 (Reference) | 254 (72.6) | 202 (78.0) | 1 (Reference) | 113 (75.3) | 165 (68.8) | 1 (Reference) | |||
| AG | 129 (25.8) | 123 (24.6) | – | 94 (26.9) | 53 (20.5) | – | 35 (23.3) | 70 (29.2) | – | |||
| GG | 4 (0.8) | 9 (1.8) | 0.36 | – | 2 (0.6) | 4 (1.5) | 0.10 | – | 2 (1.3) | 5 (2.1) | 0.36 | – |
| AG+GG | 133 (26.6) | 132 (26.4) | 0.94 | 0.99 (0.75–1.31) | 96 (27.4) | 57 (22.0) | 0.13 | 0.75 (0.51–1.09) | 37 (24.7) | 75 (31.3) | 0.16 | 1.39 (0.88–2.20) |
| Rs607887 | ||||||||||||
| CC | 297 (59.4) | 278 (55.6) | 1 (Reference) | 204 (58.3) | 134 (51.7) | 1 (Reference) | 93 (62.0) | 143 (59.6) | 1 (Reference) | |||
| TT | 24 (4.8) | 26 (5.2) | – | 14 (4.0) | 16 (6.2) | – | 10 (6.7) | 10 (4.2) | – | |||
| CT | 179 (0.358) | 196 (39.2) | 0.48 | – | 132 (37.7) | 109 (42.1) | 0.19 | – | 47 (31.3) | 87 (36.2) | 0.39 | – |
| TT+CT | 203 (40.6) | 222 (44.4) | 0.22 | 1.17 (0.91–1.50) | 146 (41.7) | 125 (48.3) | 0.11 | 1.30 (0.94–1.80) | 57 (38.0) | 97 (40.4) | 0.63 | 1.11 (0.73–1.68) |
LRP5, low-density lipoprotein receptor-related protein 5; NSCLC, non-small cell lung cancer; OR, odds ratio; CI, confidence interval.