Table V.
Genotypes of LRP5 single-nucleotide polymorphisms in squamous cell carcinoma patients and controls.
| Genotype | SCC n=169 (%) | Controls n=500 (%) | P-value | OR (95% CI) | Male SCCs n=161 (%) | Male controls n=259 (%) | P-value | OR (95% CI) | Female SCCs n=8 (%) | Female controls n=240 (%) | P-value | OR (95% CI) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rs4930573 | |||||||||||||
| CC | 117 (69.2) | 324 (64.8) | 1 (Reference) | 112 (69.6) | 169 (65.3) | 1 (Reference) | 5 (62.5) | 154 (64.2) | 1 (Reference) | ||||
| GG | 2 (1.2) | 16 (3.2) | – | 1 (0.6) | 6 (2.3) | – | 1 (12.5) | 10 (4.2) | – | ||||
| CG | 50 (29.6) | 160 (32.0) | 0.28 | – | 48 (29.8) | 84 (32.4) | 0.33 | – | 2 (25.0) | 76 (31.6) | 0.52 | – | |
| CG+GG | 52 (30.8) | 176 (35.2) | 0.29 | 0.82 (0.56–1.19) | 49 (30.4) | 90 (34.7) | 0.36 | 0.82 (0.54–1.25) | 3 (37.5) | 86 (35.8) | 0.92 | 1.07 (0.25–4.61) | |
| Rs312009 | |||||||||||||
| CC | 103 (60.9) | 291 (0.582) | 1 (Reference) | 96 (59.6) | 145 (56.0) | 1 (Reference) | 7 (87.5) | 146 (60.8) | 1 (Reference) | ||||
| TT | 7 (4.1) | 36 (0.072) | – | 7 (4.4) | 15 (5.8) | – | 0 (0.0) | 21 (8.7) | – | ||||
| CT | 59 (34.9) | 173 (0.346) | 0.37 | – | 58 (36.0) | 99 (38.2) | 0.69 | – | 1 (12.5) | 73 (30.4) | 0.30 | – | |
| TT+CT | 66 (39.1) | 209 (0.418) | 0.53 | 1.12 (0.79–1.60) | 65 (40.4) | 114 (44.0) | 0.46 | 1.16 (0.78–1.73) | 1 (12.5) | 94 (39.2) | 0.13 | 4.51 (0.55–37.22) | |
| Rs312014 | |||||||||||||
| CC | 58 (34.3) | 145 (29.0) | 1 (Reference) | 56 (34.8) | 74 (28.6) | 1 (Reference) | 2 (25.0) | 71 (29.6) | 1(Reference) | ||||
| CG | 81 (47.9) | 240 (48.0) | – | 76 (47.2) | 125 (48.3) | – | 5 (62.5) | 114 (47.5) | – | ||||
| GG | 30 (17.8) | 115 (23.0) | 0.25 | – | 29 (18.0) | 60 (23.2) | 0.29 | – | 1 (12.5) | 55 (22.9) | 0.67 | – | |
| GG+CG | 111 (65.7) | 355 (71.0) | 0.19 | 1.28 (0.88–1.86) | 105 (65.2) | 185 (71.4) | 0.18 | 1.33 (0.882.03) | 6 (75.0) | 169 (70.4) | 0.78 | 1.26 (0.25–6.40) | |
| Rs3781590 | |||||||||||||
| CC | 131 (77.5) | 402 (80.4) | 1 (Reference) | 126 (78.3) | 218 (84.2) | 1 (Reference) | 5 (62.5) | 183 (76.2) | 1 (Reference) | ||||
| TT | 0 (0.0) | 3 (0.6) | – | 0 (0.0) | 0 (0.0) | – | 0 (0.0) | 3 (1.3) | – | ||||
| CT | 38 (22.5) | 95 (19.0) | 0.38 | – | 35 (21.7) | 41(15.8) | 0.13 | – | 3 (37.5) | 54 (22.4) | 0.59 | – | |
| TT+CT | 38 (22.5) | 98 (19.6) | 0.42 | 0.84 (0.55–1.28) | 35 (21.7) | 41 (15.8) | 0.13 | 0.68 (0.41–1.12) | 3 (37.5) | 57 (23.7) | 0.37 | 0.52 (0.12–2.24) | |
| Rsa312015 | |||||||||||||
| GG | 69 (40.8) | 181 (36.2) | 1 (Reference) | 65 (40.4) | 94 (36.3) | 1 (Reference) | 4 (50.0) | 87 (36.2) | 1 (Reference) | ||||
| CC | 26 (15.4) | 80 (16.0) | – | 24 (14.9) | 40 (15.4) | – | 2 (25.0) | 40 (16.7) | – | ||||
| CG | 74 (43.8) | 239 (47.8) | 0.55 | – | 72 (44.7) | 125 (48.3) | 0.70 | – | 2 (25.0) | 113 (47.1) | 0.47 | – | |
| CC+CG | 100 (59.2) | 319 (63.8) | 0.28 | 1.21 (0.85–1.74) | 96 (59.6) | 165 (63.7) | 0.40 | 1.19 (0.79–1.78) | 4 (0.500) | 153 (63.7) | 0.43 | 1.76 (0.43–7.21) | |
| Rs491347 | |||||||||||||
| TT | 112 (66.3) | 311 (62.2) | 1 (Reference) | 107 (66.5) | 149 (57.5) | 1 (Reference) | 5 (62.5) | 161 (67.1) | 1 (Reference) | ||||
| CC | 7 (4.1) | 16 (3.2) | – | 6 (3.7) | 11 (4.3) | – | 1 (12.5) | 5 (2.1) | – | ||||
| CT | 50 (29.6) | 173 (34.6) | 0.45 | – | 48 (29.8) | 99 (38.2) | 0.19 | – | 2 (25.0) | 74 (30.8) | 0.17 | – | |
| CC+CT | 57 (33.7) | 189 (37.8) | 0.34 | 1.19 (0.83–1.72) | 54 (33.5) | 110 (42.5) | 0.07 | 1.46 (0.97–2.20) | 3 (37.5) | 79 (32.9) | 0.79 | 0.82 (0.19–3.51) | |
| Rs1784235 | |||||||||||||
| TT | 112 (66.3) | 312 (62.4) | 1 (Reference) | 108 (67.1) | 149 (57.5) | 1 (Reference) | 4 (50.0) | 162 (67.5) | 1 (Reference) | ||||
| CC | 7 (4.1) | 16 (3.2) | – | 6 (3.7) | 11 (4.2) | – | 1 (12.5) | 5 (2.1) | – | ||||
| CT | 50 (29.6) | 172 (34.4) | 0.47 | – | 47 (29.2) | 99 (38.2) | 0.14 | – | 3 (37.5) | 73 (30.4) | 0.14 | – | |
| CC+CT | 57 (33.7) | 188 (37.6) | 0.37 | 1.18 (0.82–1.71) | 53 (32.9) | 110 (42.5) | 0.05 | 1.50 (1.00–2.27) | 4 (50.0) | 78 (32.5) | 0.30 | 0.48 (0.12–1.98) | |
| Rs648438 | |||||||||||||
| TT | 145 (85.8) | 395 (79.0) | 1 (Reference) | 140 (87.0) | 205 (79.2) | 1 (Reference) | 5 (62.5) | 189 (78.7) | 1 (Reference) | ||||
| CC | 3 (1.8) | 8 (1.6) | – | 3 (1.9) | 4 (1.5) | – | 0 (0.0) | 4 (1.7) | – | ||||
| CT | 21 (12.4) | 97 (19.4) | 0.12 | – | 18 (11.1) | 50 (19.3) | 0.09 | – | 3 (37.5) | 47 (19.6) | 0.44 | – | |
| CC+CT | 24 (14.2) | 105 (21.0) | 0.05 | 1.61 (0.9–2.60) | 21 (13.0) | 54 (20.8) | 0.04 | 1.77 (1.02–3.04) | 3 (37.5) | 51 (21.3) | 0.27 | 0.45 (0.10–1.95) | |
| Rs3736228 | |||||||||||||
| CC | 110 (65.1) | 306 (61.2) | 1 (Reference) | 106 (65.8) | 146 (56.4) | 1 (Reference) | 4 (50.0) | 159 (66.2) | 1 (Reference) | ||||
| TT | 7 (4.1) | 16 (3.2) | – | 6 (3.7) | 11 (4.2) | – | 1 (12.5) | 5 (2.1) | – | ||||
| CT | 52 (30.8) | 178 (35.6) | 0.47 | – | 49 (30.5) | 102 (39.4) | 0.15 | – | 3 (37.5) | 76 (31.7) | 0.14 | – | |
| TT+CT | 59 (34.9) | 194 (38.8) | 0.36 | 1.18 (0.82–1.70) | 55 (34.2) | 113 (43.6) | 0.05 | 1.49 (0.99–2.24) | 4 (50.0) | 81 (33.8) | 0.34 | 0.51 (0.12–2.09) | |
| Rs624947 | |||||||||||||
| AA | 122 (72.2) | 368 (73.6) | 1 (Reference) | 117 (72.7) | 202 (78.0) | 1 (Reference) | 5 (62.5) | 165 (68.8) | 1 (Reference) | ||||
| AG | 46 (27.2) | 123 (24.6) | – | 43 (26.7) | 53 (20.5) | – | 3 (37.5) | 70 (29.2) | – | ||||
| GG | 1 (0.6) | 9 (1.8) | 0.45 | – | 1 (0.6) | 4 (1.5) | 0.25 | – | 0 (0.0) | 5 (2.1) | 0.82 | – | |
| AG+GG | 47 (27.8) | 132 (26.4) | 0.72 | 0.93 (0.63–1.38) | 44 (27.3) | 57 (22.0) | 0.21 | 0.75 (0.48–1.18) | 3 (37.5) | 75 (31.3) | 0.71 | 0.76 (0.18–3.25) | |
| Rs607887 | |||||||||||||
| CC | 101 (59.8) | 278 (55.6) | 1 (Reference) | 97 (60.2) | 134 (51.7) | 1 (Reference) | 4 (50.0) | 143 (59.6) | 1 (Reference) | ||||
| TT | 9 (5.3) | 26 (5.2) | – | 8 (5.0) | 16 (6.2) | – | 1 (12.5) | 10 (4.2) | – | ||||
| CT | 59 (34.9) | 196 (39.2) | 0.61 | – | 56 (34.8) | 109 (42.1) | 0.23 | – | 3 (37.5) | 87 (36.2) | 0.51 | – | |
| TT+CT | 68 (40.2) | 222 (44.4) | 0.35 | 1.19(0.83–1.69) | 64 (39.8) | 125 (48.3) | 0.09 | 1.41 (0.95–2.11) | 4 (50.0) | 97 (40.4) | 0.59 | 0.68 (0.17–2.78) |
LRP5, low-density lipoprotein receptor-related protein 5; SCC, squamous cell carcinoma; OR, odds ratio; CI, confidence interval.