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. 2016 Aug 2;12(4):2664–2673. doi: 10.3892/ol.2016.4932

Table IV.

Association between SHh and PTCH1 expression and clinicopathological characteristics.

SHh PTCH1
Characteristics Patients, n (%) IOD (mean ± SD) P-value IOD (mean ± SD) P-value
Pathological gradea
  Well/moderately differentiated 47 (67.14) (2.98±0.82)×105 <0.001a (1.60±0.49)×105 0.023b
  Poorly differentiated 19 (27.14) (3.95±0.92)×105 (1.96±0.73)×105
Invasive extentc
  Stage 1 22 (31.43) (3.04±0.83)×105   0.463d (1.81±0.57)×105 0.473d
  Stage 2 20 (28.57) (3.25±1.06)×105   0.413e (1.68±0.38)×105 0.911e
  Stage 3 28 (40.00) (3.47±0.94)×105   0.104f (1.66±0.69)×105 0.373f
Lymph node statusg
  N0 44 (62.86) (3.13±0.87)×105   0.113 (1.75±0.50)×105 0.528
  N1 24 (34.29) (3.52±1.05)×105 (1.66±0.72)×105
Age, years
  ≤40 20 (28.57) (3.19±1.06)×105   0.601h (1.74±0.54)×105 0.802k
  41–56 41 (58.57) (3.32±0.96)×105   0.767i (1.67±0.44)×105
  ≥56   9 (12.86) (3.27±0.95)×105   0.933j (1.86±0.11)×105
a

Pathological stage was undetermined in 4 patients.

b

Independent samples t-test.

c

According to the American Joint Committee on Cancer classification. Equal variance, Fisher's least significant difference test:

d

Stage 1 vs. stage 2

e

stage 2 vs. stage 3

f

stage 1 vs. stage 3

g

Lymph node status was undetermined in 2 patients.

h

patients in the ≤40-year-old group compared with patients in the 41–56-year-old group

i

patients in the 41–56-year-old compared with patients in the ≥56-year-old group

j

patients in the ≤40-year-old group compared with patients in the ≥56-year-old group.

k

Unequal variance, Kruskal-Wallis test. SHh, Sonic hedgehog; PTCH1, patched 1; IOD, integrated optical density; SD, standard deviation.