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. 2016 Aug 4;12(4):2027–2038. doi: 10.3892/etm.2016.3570

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Copyright: © Xiang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Bisoprolol attenuated cardiac hypertrophy induced by pressure overload. (A) Histological changes. Upper images, gross observation of hearts; middle images, representative images of hematoxylin and eosin staining of whole hearts (magnification, ×1) and sections (magnification, ×40); lower images, wheat germ agglutinin-fluorescein isothiocyanate staining (magnification, ×40) at 8 weeks post-aortic banding (AB) surgery. (B) Graphical results of HW/BW ratio, LW/BW ratio, HW/TL ratio, and myocyte cross-sectional areas (n=100 cells per group) at 8 weeks post-AB surgery (n=6). *P<0.05 vs. the other five groups, **P<0.05 vs. M-Biso AB and H-Biso AB groups. Biso, bisoprolol; L, low-dose; M, middle-dose; H, high-dose; HW, heart weight; BW, body weight; TL, tibial length. (C) Representative western blots of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and β-major histocompatibility complex (MHC) at 8 weeks post-sham and aortic banding (AB) surgery. (D) Quantitative polymerase chain reaction analysis of ANP, BNP and β-MHC at 8 weeks post-sham and AB surgery (n=3 per group). Values represent the mean ± standard error of the mean. *P<0.05 vs. all other groups. **P<0.05 vs. M-Biso AB and H-Biso AB. Biso, bisoprolol; L, low-dose; M, middle-dose; H, high-dose; GAPDH, glyceraldehyde 3-phosphate dehydrogenase.

Figure 3. — Bisoprolol attenuated cardiac hypertrophy induced by pressure overload. (A) Histological changes. Upper images, gross observation of hearts; middle images, representative images of hematoxylin and eosin staining of whole hearts (magnification, ×1) and sections (magnification, ×40); lower images, wheat germ agglutinin-fluorescein isothiocyanate staining (magnification, ×40) at 8 weeks post-aortic banding (AB) surgery. (B) Graphical results of HW/BW ratio, LW/BW ratio, HW/TL ratio, and myocyte cross-sectional areas (n=100 cells per group) at 8 weeks post-AB surgery (n=6). *P<0.05 vs. the other five groups, **P<0.05 vs. M-Biso AB and H-Biso AB groups. Biso, bisoprolol; L, low-dose; M, middle-dose; H, high-dose; HW, heart weight; BW, body weight; TL, tibial length. (C) Representative western blots of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and β-major histocompatibility complex (MHC) at 8 weeks post-sham and aortic banding (AB) surgery. (D) Quantitative polymerase chain reaction analysis of ANP, BNP and β-MHC at 8 weeks post-sham and AB surgery (n=3 per group). Values represent the mean ± standard error of the mean. *P<0.05 vs. all other groups. **P<0.05 vs. M-Biso AB and H-Biso AB. Biso, bisoprolol; L, low-dose; M, middle-dose; H, high-dose; GAPDH, glyceraldehyde 3-phosphate dehydrogenase.