Table I.
Echocardiograhic parameters of C57BL/6 mice at baseline.
| Sham | AB | |||||
|---|---|---|---|---|---|---|
| Parameter | Saline | Biso | Saline | L-Biso | M-Biso | H-Bsio |
| Number | 12 | 12 | 14 | 16 | 16 | 16 |
| BW (g) | 24.97±0.24 | 24.87±0.17 | 24.91±0.18 | 25.16±0.13 | 25.50±0.20 | 25.10±0.24 |
| HR (bpm) | 495.50±4.80 | 502.45±4.24 | 508.00±5.43 | 508.94±6.20 | 505.44±6.94 | 506.81±5.56 |
| LVESD (mm) | 2.84±0.09 | 3.05±0.11 | 2.78±0.12 | 2.81±0.06 | 2.91±0.07 | 2.99±0.07 |
| LVEDD (mm) | 4.07±0.10 | 4.34±0.11 | 4.30±0.11 | 4.14±0.06 | 4.17±0.08 | 4.30±0.10 |
| IVSD (mm) | 0.46±0.02 | 0.48±0.01 | 0.49±0.01 | 0.49±0.01 | 0.47±0.02 | 0.50±0.02 |
| LVPWD (mm) | 0.70±0.02 | 0.69±0.02 | 0.71±0.02 | 0.70±0.01 | 0.73±0.01 | 0.70±0.02 |
| FS (%) | 30.40±0.83 | 29.73±0.91 | 30.62±0.80 | 31.13±0.76 | 30.00±0.78 | 30.56±0.86 |
| EF (%) | 64.60±1.26 | 63.45±1.38 | 64.54±1.04 | 63.50±0.93 | 64.25±1.21 | 64.31±0.83 |
All values are the mean ± standard error of the mean. AB, aortic banding; Biso, bisoprolol; L, low-dose; M, middle-dose; H, high-dose; BW, body weight; HR, heart rate; LVESD, left ventricular end-systolic diameter; LVEDD, left ventricular end-diastolic diameter; IVSD, left ventricular septum diastolic; LVPWD, left ventricular posterior wall diameter; FS, fractional shortening; EF, ejection fraction. The echocardiographic parameters of all groups exhibited no statistically significant differences at baseline.