Table II.

Echocardiographic parameters of C57BL/6 mice at 8 weeks after sham or AB surgery.

	Sham		AB
Parameter	Saline	Biso	Saline	L-Biso	M-Biso	H-Bsio
Number	5	6	4	6	6	6
BW (g)	31.10±0.68	27.11±0.47	26.56±0.68a	27.53±0.64	28.28±0.59	26.77±1.15
HR (bpm)	550.80±21.31	537.67±21.80	482±21.00	548.83±17.51	544.17±21.72	533.00±24.89
LVESD (mm)	3.02±0.17	2.98±0.11	4.80±0.07a	3.52±0.17b	4.32±0.17	4.55±0.15
LVEDD (mm)	4.32±0.14	4.28±0.08	6.13±0.13a	4.87±0.28b	5.52±0.19	5.83±0.14
IVSD (mm)	0.52±0.03	0.47±0.02	0.70±0.01a	0.65±0.03b	0.55±0.03	0.54±0.03
LVPWD (mm)	0.69±0.03	0.65±0.03	0.83±0.02a	0.76±0.03	0.71±0.04	0.68±0.03
FS (%)	30.60±0.60	30.17±1.11	22.50±0.96a	30.00±0.77	26.00±1.15c	22.00±1.03d
EF (%)	64.40±1.89	63.00±2.14	48.25±1.60a	62.67±1.94	56.17±2.27c	50.17±1.89d

All values are the mean ± standard error of the mean. AB, aortic banding; Biso, bisoprolol; L, low-dose; M, middle-dose; H, high-dose; BW, body weight; HR, heart rate; LVESD, left ventricular end-systolic diameter; LVEDD, left ventricular end-diastolic diameter; IVSD, left ventricular septum diastolic; LVPWD, left ventricular posterior wall diameter; FS, fractional shortening; EF, ejection fraction.

^aP<0.05 vs. all other groups

^bP<0.05 vs. M-Biso AB and H-Biso AB

^cP<0.05 vs. H-Biso AB

^dP<0.05 vs. L-Biso and M-Biso AB.