Table III.
Association analysis of DNMT1, DNMT3A and DNMT3B SNPs in gout.
| Cohort | |||||
|---|---|---|---|---|---|
| Gene | Patient | Control | χ2 | P-value | OR (95% CI) |
| DNMT1 rs2228611 | |||||
| G/G | 179 (0.533) | 197 (0.644) | |||
| A/G | 136 (0.405) | 100 (0.327) | |||
| A/A | 21 (0.062) | 9 (0.029) | 9.378 | 0.007 | |
| G | 494 (0.735) | 484 (0.807) | |||
| A | 178 (0.265) | 118 (0.193) | 9.772 | 0.002 | 1.508 (1.158–1.964) |
| DNMT3A rs1550117 | |||||
| G/G | 219 (0.652) | 208 (0.680) | |||
| A/G | 111 (0.330) | 94 (0.307) | |||
| A/A | 6 (0.018) | 4 (0.013) | 0.594 | 0.707 | |
| G | 549 (0.817) | 510 (0.833) | |||
| A | 123 (0.183) | 102 (0.167) | 0.692 | 0.441 | 0.893 (0.669–1.192) |
| DNMT3B rs2424913 | |||||
| C/C | 8 (0.024) | 9 (0.029) | |||
| C/T | 64 (0.190) | 68 (0.222) | |||
| T/T | 264 (0.786) | 229 (0.748) | 1.312 | 0.531 | |
| C | 80 (0.119) | 86 (0.141) | |||
| T | 592 (0.881) | 526 (0.859) | 1.266 | 0.252 | 1.210 (0.873–1.677) |
SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.