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. 2016 Aug 5;12(4):2599–2605. doi: 10.3892/ol.2016.4956

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Drug resistance genes and stemness genes were activated by cisplatin (CDDP) in vivo. The osteosarcoma tissues were cultured with or without CDDP in the mouse model. (A and B) Quantitative polymerase chain reaction (qPCR) data showed that the treatment of the osteosarcoma tissues with CDDP resulted in the increased expression of the drug resistance genes, (A) multi-drug resistance association protein-1 (MRP1) and (B) multi-drug resistance gene-1 (MDR1). (C-F) qPCR data showed that the expression of the stemness genes, octamer-binding transcription factor 4 (OCT4), SRY (sex determining region Y)-box 2 (SOX2), telomerase reverse transcriptase (TERT) and Nanog, was elevated following treatment with CDDP. Results represent the mean ± standard deviation of three individual experiments. *P<0.05 vs. control.