Table I.
Association between the expression of miR-132 and clinicopathological features in patients with HCC.
| Relative expression of miRNA-132 (2−ΔΔCq) | ||||||
|---|---|---|---|---|---|---|
| Clinicopathological features | N | Mean ± SD | t-value | P-value | ||
| Tissue | −5.731 | <0.001 | ||||
| Adjacent non-cancerous liver | 95 | 2.7326±1.1475 | ||||
| HCC | 95 | 1.9245±0.7564 | ||||
| Age | 0.696 | 0.488 | ||||
| ≥50 years | 46 | 1.9804±0.8967 | ||||
| <50 years | 49 | 1.8720±0.6006 | ||||
| Gender | 0.381 | 0.704 | ||||
| Male | 75 | 1.9399±0.7858 | ||||
| Female | 20 | 1.8670±0.6490 | ||||
| Differentiation | 0.272 | 0.763 | ||||
| High | 6 | 1.9167±0.9745 | ||||
| Moderate | 60 | 1.8837±0.7898 | ||||
| Low | 29 | 2.0107±0.6522 | ||||
| Size | 0.007 | 0.994 | ||||
| <5 cm | 8 | 1.9233±0.8599 | ||||
| ≥5 cm | 77 | 1.9248±0.7363 | ||||
| Tumor nodes | 0.370 | 0.712 | ||||
| Single | 52 | 1.9508±0.7608 | ||||
| Multi | 43 | 1.8928±0.7588 | ||||
| Metastasis | 2.193 | 0.031 | ||||
| Without metastasis | 46 | 2.0967±0.7740 | ||||
| With metastasis | 49 | 1.7629±0.7096 | ||||
| Clinical TNM stage | 2.323 | 0.022 | ||||
| I–II | 22 | 2.2455±0.7900 | ||||
| III–IV | 73 | 1.8278±0.7238 | ||||
| Portal vein tumor embolus | 0.261 | 0.794 | ||||
| − | 63 | 1.9390±0.8197 | ||||
| + | 32 | 1.8959±0.6243 | ||||
| Vaso-invasion | −0.044 | 0.965 | ||||
| − | 59 | 1.9219±0.8013 | ||||
| + | 36 | 1.9289±0.6873 | ||||
| Tumor capsular infiltration | 2.264 | 0.026 | ||||
| With complete capsule | 45 | 2.1058±0.7603 | ||||
| No capsule or infiltration | 50 | 1.7614±0.7219 | ||||
| HCV | 1.023 | 0.309 | ||||
| − | 63 | 1.9811±0.7596 | ||||
| + | 32 | 1.8131±0.7494 | ||||
| HBV | 4.594 | <0.001 | ||||
| − | 17 | 2.6176±0.9534 | ||||
| + | 78 | 1.7735±0.6167 | ||||
| AFP | −1.803 | 0.075 | ||||
| − | 41 | 2.0722±0.8840 | ||||
| + | 38 | 1.7634±0.5986 | ||||
| Cirrhosis | −1.654 | 0.101 | ||||
| − | 50 | 2.0452±0.7716 | ||||
| + | 45 | 1.7904±0.7241 | ||||
| NM23 | 2.146 | 0.034 | ||||
| − | 20 | 2.2410±0.6714 | ||||
| + | 75 | 1.8401±0.7594 | ||||
| MTDH1 | −0.133 | 0.895 | ||||
| − | 38 | 1.9055±0.8265 | ||||
| +/++/+++ | 51 | 1.9275±0.7251 | ||||
| MTDH2 | 0.187 | 0.852 | ||||
| -/+ | 50 | 1.9316±0.7788 | ||||
| ++/+++ | 39 | 1.9008±0.7580 | ||||
| P53 | 1.064 | 0.290 | ||||
| − | 40 | 2.0212±0.6458 | ||||
| + | 55 | 1.8542±0.8262 | ||||
| P21 | 0.201 | 0.841 | ||||
| − | 62 | 1.9360±0.7050 | ||||
| + | 33 | 1.9030±0.8558 | ||||
| VEGF | 0.431 | 0.667 | ||||
| − | 25 | 1.9808±0.7791 | ||||
| + | 70 | 1.9044±0.7528 | ||||
| Ki-67 labeling index | 2.893 | 0.005 | ||||
| Low | 47 | 2.1430±0.7889 | ||||
| High | 48 | 1.7106±0.6637 | ||||
| MVD | 1.229 | 0.222 | ||||
| Low | 47 | 2.0206±0.7705 | ||||
| High | 48 | 1.8304±0.7381 | ||||
HCC, hepatocellular carcinoma; HCV, hepatitis C virus; HBV, hepatitis B virus; AFP, α-fetoprotein; MTDH, metadherin; VEGF, vascular endothelial growth factor; MVD, microvessel density.