Table I.
Clinical characteristics of sPDA infants of the ibuprofen and acetaminophen groups.
| Characteristics | Ibuprofen group (n=43) | Acetaminophen group (n=44) | χ2/t/Z | P-value |
|---|---|---|---|---|
| Male, n (%) | 25 (58.1) | 27 (61.4) | χ2=0.094 | 0.759 |
| Hormone in full pregnancy course, n (%) | 28 (65.1) | 25 (56.8) | χ2=0.629 | 0.428 |
| Maternal infection, n (%) | 4 (9.3) | 6 (13.6) | χ2=0.089 | 0.766 |
| Premature rupture of membrane >18 h, n (%) | 8 (18.6) | 10 (22.7) | χ2=0.225 | 0.635 |
| Gestational age (weeks) | 33.4±2.1 | 33.6±2.1 | t=−0.491 | 0.625 |
| Cesarean delivery, n (%) | 24 (55.8) | 28 (63.6) | χ2=0.553 | 0.457 |
| Birth weight (g) | 2,091±657 | 2,219±606 | t=−0.946 | 0.347 |
| SGA, n (%) | 9 (20.9) | 6 (13.6) | χ2=0.811 | 0.368 |
| 5 min Apgar scoring <8, n (%) | 15 (34.9) | 18 (40.9) | χ2=0.335 | 0.563 |
| RDS, n (%) | 14 (32.6) | 12 (27.3) | χ2=0.290 | 0.590 |
| Positive pressure ventilation (days)a | 3.7 (1.9, 6.1) | 4.5 (3.0, 6.7) | Z=1.277 | 0.201 |
| Age at ultrasonic cardiogram examination (days) | 5.8±2.0 | 6.4±1.8 | t=−1.527 | 0.131 |
| Urine amount (ml/kg•h) | 2.52±0.54 | 2.48±0.76 | t=0.222 | 0.825 |
| Pulse pressure difference (mmHg) | 24.2±3.9 | 23.3±4.7 | t=0.880 | 0.381 |
| LA:Ao | 1.55±0.31 | 1.53±0.31 | t=0.323 | 0.748 |
| Arterial catheter diameter (mm) | 1.84±0.43 | 2.09±0.46 | t=−1.491 | 0.140 |
a
Positive pressure ventilation (d): range, 0–35; asymmetry coefficient was 3.181, kurtosis coefficient was 13.060, P<0.01, showed skewed distribution, presented by median (25th and 75th percentile). sPDA, symptomatic patent ductus arteriosus.