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. 2016 Aug 3;12(4):2375–2380. doi: 10.3892/ol.2016.4940

Table I.

Enriched GO functions and KEGG pathways for the upregulated and downregulated genesa.

A, Enriched GO functions for the upregulated genes
Category Term Description Gene no. Gene symbolb P-value
BP GO:0000279 M phase 53 DBF4, KNTC1, TTK 5.27×10−30
BP GO:0022402 Cell cycle process 66 DBF4, KNTC1, TTK 3.34×10−29
BP GO:0007017 Microtubule-based process 28 KIF23, CAV1, KIF4A 1.09×10−11
BP GO:0000226 Microtubule cytoskeleton organization 21 KIF23, CAV1, KIF11 7.27×10−11
BP GO:0007346 Regulation of mitotic cell cycle 19 CDC7, DLGAP5, TIPIN 6.43×10−9
BP GO:0010564 Regulation of cell cycle process 13 CDC7, DLGAP5, TIPIN 7.79×10−6
BP GO:0006259 DNA metabolic process 41 UNG, DBF4, TIPIN 1.80×10−12
BP GO:0006974 Response to DNA damage stimulus 28 UNG, TIPIN, PRKDC 5.83×10−8
B, Enriched GO functions for the downregulated genes
Category Term Description Gene no. Gene symbolb P-value
BP GO:0030855 Epithelial cell differentiation 16 ELF3, FOXA1, ANXA1 4.04×10−7
BP GO:0030216 Keratinocyte differentiation   7 SPRR1A, PPL, CNFN 3.48×10−3
BP GO:0010817 Regulation of hormone levels 12 FAM3B, FOXA1, DUOX2 5.75×10−4
BP GO:0034754 Cellular hormone metabolic process   5 DHRS9, UGT1A6, UGT1A10 4.25×10−2
BP GO:0002526 Acute inflammatory response   9 F3, CLU, SAA4 1.55×10−3
BP GO:0009611 Response to wounding 23 S100A9, ANXA1, PRDX5 3.86×10−3
BP GO:0006959 Humoral immune response   8 CFB, FOXJ1, CLU 1.89×10−3
BP GO:0002455 Humoral immune response mediated by circulating immunoglobulin   4 C7, CD55, CR2 3.12×10−2
C, Enriched KEGG pathways for the upregulated and downregulated genes
Regulation Category Term Description Gene no. Gene symbolb P-value
Up KEGG 04110 Cell cycle 21 COL4A2, COL4A1, COL3A1 3.32×10−11
KEGG 04512 ECM-receptor interaction 14 COL4A2, COL4A1, COL3A1 1.75×10−7
KEGG 03030 DNA replication   9 RFC5, DNA2, RFC3 2.74×10−6
KEGG 03430 Mismatch repair   7 RFC5, EXO1, MSH6 1.92×10−5
KEGG 04115 p53 signaling pathway   9 CCNE2, CCNB1, CDK1 3.32×10−4
Down KEGG 00980 Metabolism of xenobiotics by cytochrome P450   8 GSTA1, GSTA3, ADH1C 1.82×10−4
KEGG 00982 Drug metabolism   8 GSTA3, ADH1C, ADH7 2.25×10−4
KEGG 00830 Retinol metabolism   6 UGT1A1, UGT1A7, ALDH1A1 4.45×10−3
KEGG 00590 Arachidonic acid metabolism   5 AKR1C3, GGT6, ALOX15 2.61×10−2
KEGG 04640 Hematopoietic cell lineage   6 MS4A1, CD1C, CD1D 2.96×10−2
a

The enriched GO terms listed in the table are the functions for the top four clusters with the highest enriched score.

b

Only the most relevant genes in each category are listed. GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; ECM, extracellular matrix; BP, biological process. KNTC, kinetochore associated; KIF, kinesin family; CAV, caveolin; CDK, cyclin-dependent kinase; CDC, cell division cycle; DLGAP, discs large homolog associated protein; TIPIN timeless-interacting protein; UNG, uracil DNA glycosylase; PRKDC, protein kinase, DNA-activated, catalytic polypeptide; SPRR, small proline rich protein; PPL, periplakin; CNFN, cornifelin; DHRS, dehydrogenase/reductase (SDR family); UGT, UDP glucuronosyltransferase; ELF3, E74-like ETS transcription factor 3; FOX, forkhead box; ANX, annexin; FAM, family with sequence similarity; DUOX, dual oxidase; F3, coagulation factor III, tissue factor; CLU, clusterin; SAA4, serum amyloid A4, constitutive; S100A9, S100 calcium binding protein A9; PRDX, peroxiredoxin; CFB, complement factor B; C7, complement component 7; CD, cluster of differentiation; CR2, complement component 3d receptor 2; COL, collagen; RFC, replication factor C; DNA2, DNA replication helicase/nuclease 2; EXO, exonuclease; MSH, mutS homolog; CCN, cyclin; GSTA, glutathione S-transferase alpha; ADH, alcohol dehydrogenase; AKR, aldo-keto reductase; GGT, gamma-glutamyltransferase; ALOX15, arachidonate 15-lipoxygenase; MS4A1, membrane spanning 4-domains A1.