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Effect of treatment with two different opioids on CD8+ cells in a rat model of bone cancer pain. β-EP treatment increased the content of CD8+ cells, but morphine treatment decreased them. Flow cytometry shows CD3+ cells in the spleen of the (A) Sham surgery, (B) Surgery, (C) Morphine and (D) β-EP. (E) Quantification of (A-D). *P<0.05 vs. the sham surgery group; ΔΔP<0.01 vs. the surgery group; ••P<0.01 vs. the morphine group. n=8–10. β-EP, β-endorphin.
