Figure 2.

Expression levels of various Hedgehog signaling pathway components in proliferating SHPCs. On postoperative days 2, 3, 4, 7, 14, 21 and 30, IHH, PTCH, GLI1, GLI2 and GLI were continuously expressed in the cell homogenate of primary SHPCs, whereas SMO was only weakly expressed and SHH expression was negligible. SHPCs, small hepatocyte-like progenitor cells; M, DNA marker; N, negative control; SHH, sonic hedgehog; PTCH, patched; IHH, Indian hedgehog; SMO, smoothened; GLI, glioma-associated oncogene.