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. 2016 Aug 3;12(4):2924–2929. doi: 10.3892/ol.2016.4944

Figure 1.

Figure 1.

T-cell composition in GBM patients. (A) Gating of CD3+ T cells and their CD4 vs. CD8 expression in resected tumors. (A) Tumor leukocytes. (B) Percentages of CD3+ T cells in all undifferentiated cells in resected tumor and normal brain tissues in GBM subjects (unequal variances t-test; ***P<0.001). (C) Correlation between the percentages of T cells in tumor and brain tissues in the 5 patients with normal brain tissue attached to the tumor resection. Pearson's correlation test. (D) CD8-to-CD4 ratio in TI and PB T cells in GBM patients, calculated by dividing the percentage of CD8+ T cells by the percentage of CD4+ T cells (unequal variances t-test; ***P<0.001). (E) Correlation between the CD8-to-CD4 ratios in PB or TI T cells (Pearson's correlation test). GBM, glioblastoma; CD, cluster of differentiation; SSC, side scatter; FSC, forward scatter; TI, tumor-infiltrating; PB, peripheral blood.