Table 1. Total and IgG subclass reactivity to PvRBPs in young Papua New Guinean children.
| PvRBP1a | PvRBP1b | PvRBP2a | PvRBP2b | PvRBP2cNB | PvRBP2-P2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total IgG | IgG1 | IgG3 | Total IgG | IgG1 | Total IgG | IgG1 | IgG3 | Total IgG | IgG1 | Total IgG | IgG1 | Total IgG | IgG1 | IgG3 | |
| Level* in children (% of adult levels) | |||||||||||||||
| Median | 0.0025 (12.3) | 0.0051 (25.5) | 0.0002 (0.85) | 0.0019 (9.6) | 0.0054 (27.0) | 0.0035 (17.3) | 0.0037 (18.5) | 0.0002 (0.91) | 0.0029 (14.4) | 0.0067 (33.4) | 0.0006 (3.0) | 0.0011 (5.3) | 0.0095 (47.4) | 0.0057 (28.5) | 0.0031 (15.5) |
| IQR | 0.0010 (5.1) | 0.0025 (12.5) | 0.0001 (0.32) | 0.0010 (5.0) | 0.0033 (16.3) | 0.0013 (6.7) | 0.0011 (5.7) | 0.0001 (0.46) | 0.0013 (6.5) | 0.0024 (11.8) | 0.0003 (1.5) | 0.0005 (2.7) | 0.0041 (20.5) | 0.0025 (12.7) | 0.0012 (5.8) |
| 0.0053 (26.3) | 0.0094 (46.8) | 0.0006 (3.1) | 0.0041 (20.4) | 0.0105 (52.3) | 0.0101 (50.4) | 0.0132 (65.8) | 0.0005 (2.8) | 0.0059 (29.6) | 0.0149 (74.6) | 0.0015 (7.7) | 0.0025 (12.7) | 0.0181 (90.1) | 0.0128 (64.1) | 0.0079 (39.7) | |
| Cut-off* low antibody levels | 0.0013 (6.3) | 0.0031 (15.6) | 0.0001 (0.47) | 0.0013 (6.4) | 0.0039 (19.7) | 0.0017 (8.6) | 0.0017 (8.5) | 0.0001 (0.56) | 0.0019 (9.6) | 0.0037 (18.5) | 0.0004 (2.0) | 0.0007 (3.4) | 0.0056 (27.9) | 0.0033 (16.8) | 0.0016 (7.9) |
| Cut-off* medium antibody levels | 0.0038 (19.0) | 0.0077 (38.5) | 0.0004 (2.0) | 0.0029 (14.5) | 0.0078 (39.2) | 0.0074 (36.9) | 0.0086 (43.1) | 0.0003 (1.7) | 0.0046 (23.0) | 0.0119 (59.7) | 0.0010 (5.10) | 0.0018 (9.1) | 0.0145 (72.3) | 0.0107 (53.4) | 0.0053 (26.4) |
| Cumulative prevalence in children, n (%) | |||||||||||||||
| % of adult levels (antibody cut-off value *) | |||||||||||||||
| 1% (≥ 0.0002) | 221 (98.7) | 224 (100.0) | 106 (47.3) | 222 (99.1) | 224 (100.0) | 222 (99.1) | 218 (97.3) | 107 (47.8) | 223 (90.6) | 223 (99.6) | 190 (84.8) | 214 (95.5) | 224 (100.0) | 223 (99.6) | 215 (96.0) |
| 5% (≥ 0.001) | 169 (75.5) | 216 (96.4) | 34 (15.2) | 169 (75.5) | 218 (97.3) | 182 (81.2) | 174 (77.7) | 23 (10.3) | 181 (80.8) | 211 (94.2) | 77 (34.4) | 115 (51.3) | 223 (99.6) | 209 (93.3) | 175 (78.1) |
| 10% (≥ 0.002) | 127 (56.7) | 184 (82.1) | 16 (7.1) | 109 (48.7) | 208 (92.9) | 139 (62.1) | 139 (62.1) | 9 (4.0) | 147 (65.6) | 177 (79.0) | 45 (20.1) | 67 (29.9) | 212 (94.6) | 186 (83.0) | 142 (63.4) |
| 25% (≥ 0.005) | 57 (25.5) | 114 (50.9) | 3 (1.3) | 49 (21.9) | 123 (54.9) | 94 (42.0) | 104 (46.4) | 0 (0.0) | 65 (29.0) | 135 (60.3) | 27 (12.1) | 33 (14.7) | 158 (70.5) | 119 (53.1) | 77 (34.4) |
| 50% (≥ 0.01) | 28 (12.5) | 46 (20.5) | 1 (0.45) | 17 (7.6) | 57 (25.5) | 56 (25.0) | 67 (29.9) | 0 (0.0) | 22 (9.8) | 83 (37.1) | 15 (6.7) | 19 (8.5) | 105 (46.9) | 80 (35.7) | 46 (20.5) |
Abbreviations: IQR = Interquartile range
*Values in arbitrary units. Values were interpolated from standard curves using a 5PL logistic regression model.