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. Author manuscript; available in PMC: 2016 Sep 27.
Published in final edited form as: Acta Neuropathol. 2016 Feb 26;131(6):847–863. doi: 10.1007/s00401-016-1549-x

Fig. 1. Family pedigree and imaging, FGFR1 mutations and modelling.

Fig. 1

a) Pedigree of the family. Age in brackets = current age; y/o = years old; DNET = dysembryoplastic neuroepithelial tumor. b) H & E of the lesions from the pedigree in a); top: I.1; middle: II.1; bottom: II.2. Note the presence of the specific glioneuronal element (insets, higher magnification) with oligodendroglial-like cells and floating neurons (arrows) in all tumors. c) Magnetic resonance imaging. Fluid attenuated inversion recovery (FLAIR) studies of the brain performed in 2014 in II.2 at age 17 years (left) and in II.1 at age 19 years (right). Note the presence of cortical lesions (arrows) in addition to the previously resected and neuropathologically confirmed DNET (*). d) Chromatograms of germline and somatic mutations identified in the family shown in a); red asterisk denotes single basepair change. p.R661P screening was negative in the germline of I.2