Table 1.
Overview of toll-like receptors associated with hematologic malignancies.
| Toll-like receptor | Hematologic malignancy | Reference |
|---|---|---|
| TLR1 | Myelodysplastic syndrome (MDS), acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), multiple myeloma (MM), chronic lymphocytic leukemia (CLL) | MDS: (15, 53); ALL: (54); AML: (63, 64); MM: (72, 73); CLL: (75) |
| TLR2 | Myelodysplastic syndrome (MDS), acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), multiple myeloma (MM), chronic lymphocytic leukemia (CLL) | MDS: (15, 53, 57, 59, 60); ALL: (54); AML: (62, 64); MM: (71, 73); CLL: (75) |
| TLR3 | Acute myeloid leukemia (AML), multiple myeloma (MM), indolent non-Hodgkin’s lymphoma (iNHL) | AML: (64, 88); MM: (72, 73, 87); iNHL: (104) |
| TLR4 | Myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), multiple myeloma (MM), Mantle cell lymphoma (MCL), Follicular non-Hodgkin’s lymphoma (NHL) | (11, 52, 57, 59–61); AML: (62, 64); MM: (71–73); MCL: (74); NHL: (103) |
| TLR5 | Acute myeloid leukemia (AML), multiple myeloma (MM) | AML: (64); MM: (73) |
| TLR6 | Myelodysplastic syndrome (MDS), acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), multiple myeloma (MM), chronic lymphocytic leukemia (CLL) | MDS: (15, 53); ALL: (54); AML: (64); MM: (73); CLL: (75) |
| TLR7 | Acute myeloid leukemia (AML), activated B-cell (ABC) diffuse large B-cell lymphoma (DLBCL), multiple myeloma (MM), chronic lymphocytic leukemia (CLL) | AML: (64, 86); ABC DLBCL: (70); MM: (72, 73); CLL: (75) |
| TLR8 | Acute myeloid leukemia (AML), multiple myeloma (MM) | AML: (64, 86); MM: (72, 73) |
| TLR9 | Acute myeloid leukemia (AML), activated B-cell (ABC) diffuse large B-cell lymphoma (DLBCL), multiple myeloma (MM), chronic lymphocytic leukemia (CLL), B-cell lymphoma (BCL) | AML: (64); ABC DLBCL: (70); MM: (71–73); CLL: (75); BCL: (102) |
| TLR10 | Acute myeloid leukemia (AML), multiple myeloma (MM), chronic lymphocytic leukemia (CLL) | AML: (64); MM: (73); CLL: (75) |
| TLR11 | Acute myeloid leukemia (AML), multiple myeloma (MM) | AML: (64); MM: (73) |
| TLR12 | Acute myeloid leukemia (AML), multiple myeloma (MM) | AML: (64); MM: (73) |
| TLR13 | Acute myeloid leukemia (AML), multiple myeloma (MM) | AML: (64); MM: (73) |