Table 1.
Patient characteristics of 65 pediatric patients with a clinical pattern of hemolytic–uremic syndrome mediated by Shiga toxin-producing Escherichia coli
| Patient parametersa | All patients |
|---|---|
| Male | 52 % |
| Age of onset (years) | 2 (1–4) |
| 0–24 months (n = 18) | 17 (10–20) |
| 2–6 years (n = 33) | 3 (2–4) |
| ≥6 years (n = 14) | 11 (9–12) |
| Symptoms at presentation | |
| Fever | 27 % |
| Diarrhea, total | 97 % |
| Proportion of which was bloody | 79 % |
| Oliguria | 29 % |
| Duration (days) (n = 5) | 5 (3–8) |
| Anuria | 59 % |
| Duration (days) (n = 26) | 8 (7–10) |
| Blood pressure | |
| <95 percentile for age and height | 34 % |
| ≥95 percentile for age and height | 66 % |
| Neurological involvement | 34 % |
| Pancreas involvement | 3 % |
| Biochemical evaluation at presentation (reference range) | |
| Hemoglobin (6.0–9.0 mmol/l) | 5.8 (4.8–6.7) |
| White blood cells (5.0–13.0 × 109/l) | 15.3 (10.9–22.3) |
| Platelet count (210–430 × 109/l) | 47 (30–73.5) |
| Haptoglobin (0.3–1.6 g/l) | <0.08 (0.05–0.08) |
| LDH (<250 U/l) | 3720 (2325–5809) |
| eGFR (>90 ml/min.1.73 m2) | 15 (10–24) |
| Treatment | |
| Dialysis | 63 % |
| Duration of dialysis (days) | 10 (7–15) |
| Erythrocytes transfusion | 80 % |
| ≥ transfusions | 11 % |
| Follow up | |
| eGFR at discharge (ml/min.1.73 m2) | 55 (43–66) |
| eGFR < 60 after 5 years follow up (n = 8) (ml/min.1.73 m2) | 4 (6 %) |
| Received kidney transplantation | 1 (2 %) |
| Diseased | 1 (2 %) |
Categorical values are presented as an absolute number and/or as a percentage of the total. Continuous variables are presented as the median with the interquartile range (IQR) in parenthesis
LDH, actate dehydrogenase; eGFR, estimated glomerular filtration rate
aThe numbers of patients (n) for whom data were available are reported in parentheses