Figure 3.

Treatment with PGE2 or LPS during the second postnatal week impairs juvenile social play behavior but not motor control in males. A, Treatment with PGE2 during the second postnatal week reduced the number of play events seen in juvenile males (*p = 0.002; PN28-38) to the already low level seen in females. PGE2 treatment during the third week had no effect on either sex, although males still played more than females (*p < 0.001). There was no effect of treatment with PGE2 during either week on motor control assessed with the negative geotaxis, wire hang, and open-field test, with the latter being done at both juvenile and adult ages, although females locomoted more than males (*p < 0.05). B, An identical pattern of behavioral responses was evident in animals treated with LPS. *p < 0.005 all, 3-way ANOVAs, p < 0.05, Tukey's HSD.