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. 2016 Sep 28;36(39):10116–10127. doi: 10.1523/JNEUROSCI.4597-14.2016

Figure 6.

Figure 6.

Intra-DLS infusion of LM11A-31 reduces binge drinking of alcohol but not sucrose. A–E, Rats underwent IA20%-2BC for 7 weeks, and bilateral guide cannula were then surgically implanted in the DLS. After 1 week of recovery, rats were administered with LM11A-31 (30 μg/μl; Tep et al., 2013) or vehicle (PBS) into the DLS 2 h before the beginning of the drinking session and consumption was recorded. A, Schematic drawings of coronal sections of the rat brain showing the placement of bilateral infusion sites in the DLS (Paxinos and Watson, 2007). B, C, Alcohol (grams per kilogram per 30 min; B) and water (milliliters per kilogram per 30 min; C) intake after LM11A-31 or vehicle infusion. D, E, After 1 week of withdrawal from alcohol consumption, rats underwent 2 weeks of IA-2BC of 1% sucrose and then received intra-DLS administration of LM11A-31 (30 μg/μl) or vehicle. Sucrose consumption is presented as milliliters per kilogram per min; D and water (milliliters per kilogram per 30 min; E). Results are expressed as mean ± SEM. *p < 0.05 versus vehicle (paired t test). n = 11 (B, C) and 10 per treatment (D, E).