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. 2016 Sep 28;36(39):10141–10150. doi: 10.1523/JNEUROSCI.1054-16.2016

Figure 6.

Figure 6.

Normal paired-pulse facilitation and reduced AMPA/NMDA ratio in ApoE KO mice. A, B, Paired-pulse facilitation (ApoE3/E3, n = 6; ApoE KO, n = 9; bEKO n = 7). A, Representative traces of EPSCs. B, Normal facilitation of EPSC amplitudes evoked at 20, 50, 100, and 200 ms intervals (two-way ANOVA: pInteraction = 0.9995; pInterval < 0.0001; pgenotype = 0.9096). C–E, AMPA/NMDA ratio in ApoE3/E3, ApoE KO, and bEKO neurons (ApoE3/E3, n = 6; ApoE KO, n = 9; bEKO n = 7). C, Representative traces of EPSCs evoked at either +50 mV (top) or −70 mV (bottom). D, Average EPSC amplitude at −70 and +50 mV (two-way RM ANOVA: pInteraction = 0.6232; pmV < 0.0001; pGenotype = 0.0027; genotype post hoc test, p = n.s. at either holding potential). E, Average AMPA/NMDA ratio calculated by dividing the EPSC amplitudes evoked at −70 mV by those at +50 mV [one-way ANOVA, p = 0.0002; Tukey's post hoc test: ApoE3/E3 vs ApoE KO, *p = 0.0142; ApoE3/E3 vs bEKO, p = 0.1907 (n.s.); ApoE KO vs bEKO, **p = 0.0002].