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Activation of the vmPFC projection to the NAshell using a retro-DREADD approach does not alter cocaine seeking in the presence of cocaine cues after abstinence. A, Neither active (shaded bars) nor inactive (white bars) lever presses differed for CNO versus vehicle-treated animals during the cocaine-seeking test (p > 0.3). B, Histological verification of the extent of DREADD expression indicated robust and restricted expression in vmPFC.
