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. 2016 Sep 14;2016:6093783. doi: 10.1155/2016/6093783

Figure 7.

Figure 7

Involvement of ERK1/2 and JNK phosphorylation in myricitrin-mediated inhibition of caspase-3 activation and cytotoxicity. The H9c2 cardiomyocytes were pretreated with or without myricitrin (25 μg/mL) for 12 h prior to Dox exposure. The phosphorylation of ERK1/2 and JNK was detected using immunoblotting (a). The effects of SP600125 (a JNK-specific inhibitor) and PD98059 (an ERK-specific inhibitor) on the myricitrin-mediated inhibition of cleaved caspase-3 production and cytotoxicity in H9c2 cardiomyocytes were measured ((b), (c), and (d)). All data are expressed as the means ± SD (n = 3). # P < 0.05 versus Cont; ∗ P < 0.05 versus Dox.