Figure 9.

Involvement of ERK1/2 phosphorylation in myricitrin-mediated expression of p53, Bcl-2, and Bax. H9c2 cardiomyocytes were pretreated with or without myricitrin (25 μg/mL) for 12 h prior to Dox exposure. Effects of SP600125 (a JNK-specific inhibitor) and PD98059 (an ERK-specific inhibitor) on myricitrin-mediated activation of p53 were measured by immunoblotting assay (a). Effects of PD98059 (an ERK-specific inhibitor) and PFT-α (an p53-specific inhibitor) on the expression of Bcl-2 and Bax were measured by immunoblotting assay (b).