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. 2016 Sep 28;7:169. doi: 10.3389/fgene.2016.00169

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Copyright © 2016 Struebing, Lee, Williams and Geisert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation network of Glaucoma Severity Score (GSS) to RGC markers during glaucoma progression. The GSS is a visual grading system identifying axonal damage in the optic nerve and consists of 4 stages: no damage, light, medium, and severe damage. These stages are inversely correlated (dashed blue) to the expression levels of most RGC markers, suggesting that as RGCs die and axonal damage increases, mRNA expression of RGC marker genes decreases (most likely due to decrease in RGC number). The decrease of RGC marker gene expression is strongly correlated across glaucoma stages (red, r for all >0.9). Markers for ipRGCs (Opn4) and alpha-RGCs (Kcng4 and Spp1) do not correlate to GSS, possibly indicating their preferential survival.