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. 2016 Sep 1;116(4):659–668. doi: 10.1160/TH16-03-0179

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© The Authors 2016

This is an open access article under the terms of the Creative Commons License, wich permits use and distribution in any medium, provided the original work is properly cited and is not used for commercial purposes and no modifications or adaptations are made.

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Figure 1: — Patient enrolment and study flow diagram. The diagram shows the flow and disposition of patients in the study. Following screening, 27 patients were enrolled in the study. All patients participated in PK evaluation of 50 IU/kg rIX-FP. A subset of patients (n=17) also participated in a PK evaluation of their previous FIX product (pdFIX or rFIX). All patients were assigned weekly prophylaxis with a dose of 35–50 IU/kg. All patients completed the study. FIX, factor IX; pdFIX, plasma-derived FIX; PK, pharmacokinetics; rFIX, recombinant FIX; rIX-FP, recombinant fusion protein linking coagulation factor IX with albumin.