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. 2016 Aug 25;6(11):1988–1999. doi: 10.7150/thno.9150

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A high level of DNMT3A/ISGF3γ interaction correlates with a poor level of sensitivity to temozolomide/irradiation-induced cell death. A. Graph illustrates the correlation existing between the overall survival (OS) of 31 GBM patients and the percentage of temozolomide/irradiation-induced cell death (TMZ/Irrad-induced cell death) of primary cultured tumor cells (PCTC) issue to the corresponding GBM. A circle represents a couple patient/PCTC issues from the considered patient. p and r values were obtained by performing a Pearson's test. B. Schematic representation of the temozolomide/irradiation-induced cell death. C. Graph illustrates the existing correlation between the percentage of temozolomide/irradiation-induced cell death and the number of DNMT3A/D3A-BP interaction of interest. The number of DNMT3A/D3A-BP interaction was estimated by P-LISA. A circle represents a PCTC. p and r values were obtained by performing a Pearson's test.