Table 4.
Concordance of mutants detected in plasma by ddPCR and their status in paired tumor tissues.
| Plasma DNA | Tumor tissue | Total | Concordance (95% CI) | |
|---|---|---|---|---|
| Sensitivity (95% CI) | ||||
| + | - | Specificity (95% CI) | ||
| TP53 (747G>T) | ||||
| + | 1 | 5 | 6 | 85.4% * (71.6%-93.1% ) |
| - | 1 | 34 | 35 | 50% (9.5%-90.6%) |
| Total | 2 | 39 | 41 | 87.2% (73.3%-94.4%) |
| TERT (c.1-124C>T) | ||||
| + | 5 | 5 | 10 | 80.5% * (66.0%-89.8%) |
| - | 3 | 28 | 31 | 62.5% (30.6%-86.3%) |
| Total | 8 | 33 | 41 | 84.9% (69.1%-93.4%) |
| CTNNB1 (c.121A>G) | ||||
| + | 0 | 5 | 5 | 87.8% (74.5%-94.7%) |
| - | 0 | 36 | 36 | NA |
| Total | 0 | 41 | 41 | 87.8% (74.5%-94.7%) |
| CTNNB1 (c.133T>C) | ||||
| + | 0 | 5 | 5 | 87.8% (74.5%-94.7%) |
| - | 0 | 36 | 36 | NA |
| Total | 0 | 41 | 41 | 87.8% (74.5%-94.7%) |
95% CI, 95% confidence interval; *, P < 0.05; NA, not applicable.