Table 6.
Hazard ratio for death from all causes in African Americans vs. Caucasians after initial surgical diagnosis of breast cancer stratified by four variables: age, (10 yr. increments), stage, grade and ER status, or age, stage, grade and PR status.
| Age | Stage | Hazard Ratio (Confidence Intervals) | p (Pearson Chi Square) | Hazard Ratio (Confidence Intervals) | p (Pearson Chi Square) | Hazard Ratio (Confidence Intervals) | p (Pearson Chi Square) | Hazard Ratio (Confidence Intervals) | p (Pearson Chi Square) |
|---|---|---|---|---|---|---|---|---|---|
| ER+ | ER- | PR+ | PR- | ||||||
| Grade 1 | |||||||||
| 40 | I | 1.88 (0.94-3.76) | N.S.* | 1.58 (0.19-12.9) | N.S. | 2.16 (1.08-4.32) | 0.0305 | 0.75 (0.10-5.78) | N.S. |
| 50 | I | 3.16 (2.26-4.43) | < 10-6 | 1.01 (0.23-4.41) | N.S. | 3.00 (2.08-4.31) | < 10-6 | 2.38 (1.12-5.08) | 0.0249 |
| 60 | I | 1.68 (1.29-2.18) | 0.0001 | 1.29 (0.52-3.24) | N.S. | 1.74 (1.31-2.31) | 0.0002 | 1.34 (0.76-2.36) | N.S. |
| 70 | I | 1.38 (1.13-1.68) | 0.0017 | 0.74 (0.32-1.70) | N.S. | 1.46 (1.18-1.82) | 0.0006 | 0.95 (0.61-1.48) | N.S. |
| 80 | I | 1.08 (0.89-1.30) | N.S. | 1.14 (0.36-3.66) | N.S. | 1.09 (0.88-1.36) | N.S. | 1.05 (0.72-1.54) | N.S. |
| 40 | II | 1.53 (0.72-3.22) | N.S. | 3.59 (0.97-13.3) | N.S. | 1.52 (0.39-3.36) | N.S. | 3.14 (1.03-9.57) | 0.0442 |
| 50 | II | 1.96 (1.29-2.99) | 0.0017 | 1.81 (0.73-4.49) | N.S. | 2.17 (1.42-3.32) | 0.0003 | 1.38 (0.58-3.30) | N.S. |
| 60 | II | 2.04 (1.49-2.78) | 8.0 x 10-6 | 1.80 (0.53-6.04) | N.S. | 2.64 (1.90-3.65) | < 10-6 | 0.63 (0.27-1.46) | N.S. |
| 70 | II | 1.21 (0.87-1.69) | N.S. | 1.00 (0.42-2.39) | N.S. | 1.15 (0.80-1.66) | N.S. | 1.21 (0.67-2.18) | N.S. |
| 80 | II | 1.60 (1.24-2.07) | 0.0003 | 0.80 (0.11-5.89) | N.S. | 1.61 (1.22-2.12) | 0.0007 | 1.41 (0.74-2.69) | N.S. |
| 40 | III | 1.24 (0.55-2.77) | N.S. | - | N.S. | 1.25 (0.55-2.81) | N.S. | - | N.S. |
| 50 | III | 1.69 (0.92-3.13) | N.S. | 8,07 (1.90-34.4) | 0.0047 | 1.57 (0.80-3.05) | N.S. | 4.46 (1.71-11.6) | 0.0022 |
| 60 | III | 3.09 (1.88-5.01) | 8.8 x 10-6 | 4.08 (0.88-19.0) | N.S. | 2.63 (1.46-4.73) | 0.0013 | 4.26 (1.88-9.67) | 0.0005 |
| 70 | III | 0.95 (0.44-2.05) | N.S. | 4.60 (1.13-18.7) | 0.0328 | 1.06 (0.46-2.43) | N.S. | 2.12 (0.72-6.24) | N.S. |
| 80 | III | 1.60 (0.97-2.64) | N.S. | 1.73 (0.38-7.92) | N.S. | 1.62 (0.95-2.77) | N.S. | 1.69 (0.60-4.73) | N.S. |
| Grade 2 | |||||||||
| 40 | I | 1.86 (1.34-2.56) | 0.0002 | 1.51 (0.92-2.47) | N.S. | 1.86 (1.33-2.62) | 0.0003 | 1.50 (0.96-2.35) | N.S. |
| 50 | I | 2.19 (1.75-2.75) | <10-6 | 1.43 (0.95-2.16) | N.S. | 2.23 (1.75-2.85) | < 10-6 | 1.55 (1.11-2.17) | 0.0104 |
| 60 | I | 1.77 (1.52-2.07) | <10-6 | 1.60 (1.22-2.11) | 0.0008 | 1.76 (1.48-2.09) | < 10-6 | 1.82 (1.46-2.27) | < 10-6 |
| 70 | I | 1.22 (1.05-1.42) | 0.0106 | 1.41 (1.02-1.93) | 0.0348 | 1.23 (1.04-1.45) | 0.0145 | 1.30 (1.02-1.66) | 0.0347 |
| 80 | I | 1.09 (0.96-1.25) | N.S. | 1.11 (0.81-1.52) | N.S. | 1.06 (0.91-1.23) | N.S. | 1.19 (0.96-1.48) | N.S. |
| 40 | II | 1.81 (1.47-2.22) | < 10-6 | 1.24 (0.90-1.73) | N.S. | 1.74 (1.39-2.18) | 1.2 x 10-6 | 1.37 (1.03-1.81) | 0.0296 |
| 50 | II | 2.30 (1.95-2.73) | 0 | 1.37 (1.02-1.83) | 0.0361 | 2.31 (1.93-2.77) | 0 | 1.61 (1.25-2.06) | 0.0002 |
| 60 | II | 1.67 (1.44-1.94) | < 10-6 | 1.35 (1.04-1.75) | 0.0248 | 1.68 (1.43-1.99) | < 10-6 | 1.51 (1.22-1.85) | 0.0001 |
| 70 | II | 1.36 (1.16-1.59) | 0.0001 | 1.29 (0.92-1.83) | N.S. | 1.33 (1.12-1.59) | 0.0015 | 1.38 (1.08-1.76) | 0.0098 |
| 80 | II | 1.16 (1.02-1.33) | 0.0283 | 0.99 (0.73-1.33) | N.S. | 1.14 (0.99-1.32) | N.S. | 1.18 (0.94-1.48) | N.S. |
| 40 | III | 1.80 (1.45-2.23) | < 10-6 | 1.16 (0.82-1.64) | N.S. | 1.69 (1.33-2.14) | 1.7 x 10-5 | 1.39 (1.04-1.86) | 0.0245 |
| 50 | III | 1.91 (1.58-2.30) | < 10-6 | 1.41 (1.01-1.97) | 0.0457 | 2.00 (1.64-2.44) | < 10-6 | 1.33 (1.01-1.75) | 0.0449 |
| 60 | III | 1.79 (1.51-2.14) | < 10-6 | 1.33 (0.99-1.81) | N.S. | 1.92 (1.58-2.35) | < 10-6 | 1.39 (1.10-1.76) | 0.0056 |
| 70 | III | 1.45 (1.18-1.78) | 0.0005 | 1.41 (0.92-2.16) | N.S. | 1.59 (1.27-2.00) | 5.1 x 10-5 | 1.15 (0.83-1.60) | N.S. |
| 80 | III | 1.40 (1.15-1.71) | 0.0009 | 1.35 (0.91-1.98) | N.S. | 1.29 (1.02-1.64) | 0.0331 | 1.50 (1.15-1.96) | 0.0031 |
| Grade 3 | |||||||||
| 40 | I | 2.16 (1.61-2.89) | < 10-6 | 1.56 (1.20-2.02) | 0.0008 | 1.76 (1.27-2.43) | 0.0006 | 1.77 (1.39-2.26) | 4.2 x 10-6 |
| 50 | I | 2.19 (1.70-2.82) | < 10-6 | 1.49 (1.22-1.83) | 0.0001 | 2.00 (1.51-2.64) | 1.4 x 10-6 | 1.62 (1.34-1.96) | < 10-6 |
| 60 | I | 1.37 (1.09-1.72) | 0.0066 | 1.45 (1.20-1.74) | 8.8 x 10-5 | 1.61 (1.27-2.03) | 8.3 x 10-5 | 1.34 (1.12-1.60) | 0.0014 |
| 70 | I | 1.29 (1.03-1.60) | 0.0258 | 1.41 (1.15-1.73) | 0.0011 | 1.24 (0.97-1.59) | N.S. | 1.42 (1.18-1.71) | 0.0003 |
| 80 | I | 1.09 (0.88-1.35) | N.S. | 1.16 (0.91-1.48) | N.S. | 1.00 (0.79-1.26) | N.S. | 1.26 (1.01-1.57) | 0.0375 |
| 40 | II | 1.66 (1.40-1.96) | < 10-6 | 1.47 (1.30-1.66) | <10-6 | 1.66 (1.40-1.97) | < 10-6 | 1.49 (1.32-1.68) | < 10-6 |
| 50 | II | 1.54 (1.31-1.80) | < 10-6 | 1.34 (1.20-1.51) | <10-6 | 1.67 (1.41-1.98) | < 10-6 | 1.33 (1.19-1.49) | < 10-6 |
| 60 | II | 1.54 (1.33-1.77) | < 10-6 | 1.36 (1.21-1.53) | <10-6 | 1.52 (1.30-1.78) | < 10-6 | 1.41 (1.27-1.58) | < 10-6 |
| 70 | II | 1.47 (1.27-1.70) | < 10-6 | 1.35 (1.16-1.57) | 7.4 x 10-5 | 1.40 (1.19-1.65) | 6.3 x 10-5 | 1.44 (1.26-1.65) | < 10-6 |
| 80 | II | 1.15 (0.99-1.33) | N.S. | 1.25 (1.06-1.47) | 0.0088 | 1.10 (0.93-1.30) | N.S. | 1.28 (1.11-1.48) | 0.0006 |
| 40 | III | 1.65 (1.41-1.92) | < 10-6 | 1.44 (1.26-1.63) | < 10-6 | 1.61 (1.37-1.90) | < 10-6 | 1.49 (1.31-1.68) | < 10-6 |
| 50 | III | 1.61 (1.39-1.87) | < 10-6 | 1.38 (1.23-1.56) | < 10-6 | 1.59 (1.34-1.88) | < 10-6 | 1.44 (1.29-1.61) | < 10-6 |
| 60 | III | 1.61 (1.40-1.85) | < 10-6 | 1.50 (1.33-1.70) | < 10-6 | 1.79 (1.53-2.09) | < 10-6 | 1.46 (1.30-1.64) | < 10-6 |
| 70 | III | 1.20 (1.01-1.42) | 0.0399 | 1.23 (1.03-1.47) | 0.0246 | 1.07 (0.88-1.30) | N.S. | 1.34 (1.14-1.57) | 0.0004 |
| 80 | III | 1.34 (1.12-1.60) | 0.0012 | 1.14 (0.93-1.38) | N.S. | 1.40 (1.14-1.72) | 0.0016 | 1.13 (0.96-1.34) | N.S. |
*Not Significant.