Table 1B.

Cox proportional hazards model for progression free survival.

	Co.ef	Std.Err.	P Value	Haz.ratio(95% CI)
Combined pathway enrichment clustering	-0.255	0.134	0.048	0.775 (0.596-1.009)
Molecular subtype	-0.319	0.157	0.042	0.727 (0.535-0.988)
G-CIMP	-1.194	0.244	<0.001	0.303 (0.188-0.489)
Treatment modality	-0.783	0.211	<0.001	0.457 (0.302-0.692)
Age	0.435	0.124	<0.001	1.545 (1.211-1.972)

No. of subjects = 368; No. of event = 328; No. of censored = 40. Log likelihood = 3226.034. Method: Backward likewise

Combined pathway enrichment clustering: 0=Cluster A,B &C group. 1= Cluster D & E group.

Molecular subtype: 0= Non-proneural subtype. 1= Proneural subtype.

G-CIMP: 0=Non-C-CIMP, 1=G-CIMP

Treatment modality: 0= Without chemotherapy or radiotherapy, 1= Chemotherapy with/or radiotherapy.

Age: 0=Age<65 years, 1= Age>65 years.

KPS:0= KPS<70, 1=KPS>=70.

Gender: 0=Female, 1= Male.