Table 4.

Stratification analysis for associations between the three XPG variant genotypes and colorectal cancer risk (Combined).

Variables	rs2094258 (cases/controls)		Adjusted OR (95% CI)	P a	rs751402 (cases/controls)		Adjusted OR (95% CI)	P a	rs873601 (Case/Control)		Adjusted OR (95% CI)	P a
	CC/CT	TT			CC	CT/TT			GG/AG	AA
Median age, yr
≤Median	854/1576	131/180	1.34 (1.05-1.70)	0.017	422/640	563/1116	0.77 (0.65-0.90)	0.001	731/1399	254/357	1.35 (1.13-1.63)	0.001
>Median	799/204	117/17	1.75 (1.03-2.98)	0.039	370/84	545/137	0.90 (0.67-1.22)	0.513	699/176	217/45	1.21 (0.85-1.74)	0.294
Gender
Males	1005/1119	145/119	1.41 (1.06-1.88)	0.018	474/449	675/789	0.78 (0.65-0.94)	0.010	879/993	271/245	1.20 (0.97-1.50)	0. 100
Females	648/661	103/78	1.32 (0.93-1.88)	0.124	318/275	433/464	0.80 (0.64-1.02)	0.067	551/582	200/157	1.34 (1.03-1.76)	0.031
Tumor sites
Colon	775/1780	107/197	1.40 (1.06-1.85)	0.020	362/724	520/1253	0.80 (0.67-0.97)	0.020	666/1575	216/402	1.29 (1.04-1.59)	0.020
Rectal	878/1780	141/197	1.38 (1.06-1.79)	0.015	430/724	588/1253	0.81 (0.68-0.96)	0.016	764/1575	255/402	1.19 (0.97-1.45)	0.094
Duke stages
A+B	736/1780	107/197	1.26 (0.94-1.69)	0.123	344/724	498/1253	0.81 (0.67-0.98)	0.033	647/1575	196/402	1.03 (0.82-1.29)	0.825
C+D	917/1780	141/197	1.47 (1.14-1.90)	0.003	448/724	610/1253	0.80 (0.68-0.95)	0.009	783/1575	275/402	1.39 (1.15-1.69)	0.001

XPG, xeroderma pigmentosum group G; CI, confidence interval; OR, odds ratio.

^a Adjusted for age, gender, smoking and drinking status in logistic regression models.