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. 2016 Sep 28;6:32530. doi: 10.1038/srep32530

Table 1. Information of top-3 drug-disease module pairs.

Rank Drugs in drug module Diseases in disease module Number of drugs Number of diseases Density of drug module Density of disease module Score between drug-disease module pair
1 thiothixene, Parkinson Disease Secondary,          
  Tremor,          
chlorpromazine, Dyskinesia Drug-Induced,          
fluphenazine, Movement Disorders,          
perphenazine, Parkinsonian Disorders, 7 9 0.95 0.50 0.59
prochlorperazine Basal Ganglia Diseases,          
thioridazine, Essential Tremor,          
trifluoperazine Parkinson Disease,          
  Hepatolenticular Degeneration          
2 thiothixene, Alcohol Withdrawal Delirium,          
chlorpromazine, Schizophrenia,          
fluphenazine, Substance-Related Disorders,          
perphenazine, Bipolar Disorder,          
prochlorperazine Narcolepsy, 7 8 0.95 0.71 0.39
thioridazine, Lewy Body Disease,          
trifluoperazine Psychoses Substance-Induced,          
  Psychotic Disorders          
3   Alcoholism,          
  Depressive Disorder Major,          
protriptyline, Mood Disorders,          
imipramine, Depressive Disorder,          
cyclobenzaprine, Schizophrenia,          
nortriptyline, Substance-Related Disorders,          
amoxapine, Bipolar Disorder, 7 12 0.95 0.50 0.36
desipramine, Personality Disorders,          
amitriptyline Anxiety Disorders,          
  Depression Postpartum,          
  Dyssomnias,          
  Sleep Disorders Circadian Rhythm