Table 2. Top-20 drug and disease associations in drug-disease module pair while Rank = 1.

Rank	Drug Name	Disease Name	Score	CTD mark
1	trifluoperazine	Basal Ganglia Diseases	7.36	M
2	thorazine	Basal Ganglia Diseases	7.15	M&T
3	perphenazine	Basal Ganglia Diseases	7.01	M
4	trifluoperazine	Movement Disorders	6.92	M
5	trifluoperazine	Dyskinesia, Drug-Induced	6.81	M
6	trifluoperazine	Parkinson Disease, Secondary	6.73	M
7	Thorazine	Movement Disorders	6.71	M&T
8	Thorazine	Dyskinesia, Drug-Induced	6.62	M&T
9	prochlorperazine	Tremor	6.59	none
10	perphenazine	Movement Disorders	6.56	M&T
11	Thorazine	Parkinson Disease, Secondary	6.54	M
12	thioridazine	Basal Ganglia Diseases	6.44	M
13	perphenazine	Dyskinesia, Drug-Induced	6.43	M
14	perphenazine	Parkinson Disease, Secondary	6.36	M
15	prochlorperazine	Parkinsonian Disorders	6.34	M
16	perphenazine	Tremor	6.22	M
17	trifluoperazine	Tremor	6.22	M
18	Thorazine	Tremor	6.18	M
19	fluphenazine	Parkinsonian Disorders	6.06	inferred
20	prochlorperazine	Basal Ganglia Diseases	6.03	M

CTD mark represents a drug-disease association is curated, inferred or not existed in CTD database. Curated associations include three types: marker/mechanism (CTD mark = “M”), therapeutic (CTD mark = “T”), marker/mechanism & therapeutic (CTD mark = “M&T”). If an association is inferred by CTD, CTD mark = “inferred”, and if it is not existed in CTD, CTD mark = “none”.