Table 3. Top-20 drug and disease associations in drug-disease module pair while Rank = 2.
| Rank | Drug name | Disease name | Score | CTD mark |
|---|---|---|---|---|
| 1 | chlorpromazine | Psychotic Disorders | 5.36 | T |
| 2 | chlorpromazine | Schizophrenia | 5.19 | T |
| 3 | chlorpromazine | Psychoses, Substance-Induced | 5.19 | M&T |
| 4 | perphenazine | Schizophrenia | 5.15 | T |
| 5 | Thorazine | Bipolar Disorder | 5.07 | M&T |
| 6 | thiothixene | Psychotic Disorders | 4.91 | M&T |
| 7 | trifluoperazine | Psychotic Disorders | 4.72 | T |
| 8 | trifluoperazine | Psychoses, Substance-Induced | 4.58 | M |
| 9 | trifluoperazine | Schizophrenia | 4.57 | T |
| 10 | thioridazine | Psychoses, Substance-Induced | 4.56 | none |
| 11 | trifluoperazine | Bipolar Disorder | 4.54 | T |
| 12 | fluphenazine | Psychotic Disorders | 4.42 | T |
| 13 | fluphenazine | Schizophrenia | 4.24 | T |
| 14 | fluphenazine | Bipolar Disorder | 4.16 | T |
| 15 | fluphenazine | Psychoses, Substance-Induced | 4.10 | M |
| 16 | thorazine | Lewy Body Disease | 4.07 | inferred |
| 17 | perphenazine | Bipolar Disorder | 3.89 | T |
| 18 | prochlorperazine | Bipolar Disorder | 3.81 | none |
| 19 | perphenazine | Psychotic Disorders | 3.78 | T |
| 20 | chlorpromazine | Alcohol Withdrawal Delirium | 3.68 | none |
CTD mark represents a drug-disease association is curated, inferred or not existed in CTD database. Curated associations include three types: marker/mechanism (CTD mark = “M”), therapeutic (CTD mark = “T”), marker/mechanism & therapeutic (CTD mark = “M&T”). If an association is inferred by CTD, CTD mark = “inferred”, and if it is not existed in CTD, CTD mark = “none”.