Table 4. Top-20 drug and disease associations in drug-disease module pair while Rank = 3.

Rank	Drug name	Disease name	Score	CTD mark
1	imipramine	Bipolar Disorder	8.80	M&T
2	amitriptyline	Bipolar Disorder	8.51	T
3	imipramine	Depressive Disorder, Major	7.96	M&T
4	amitriptyline	Depressive Disorder, Major	7.86	M&T
5	desipramine	Bipolar Disorder	7.38	M&T
6	amitriptyline	Depressive Disorder	6.93	M&T
7	imipramine	Depressive Disorder	6.67	T
8	amitriptyline	Mood Disorders	6.64	M&T
9	desipramine	Depressive Disorder, Major	6.62	T
10	nortriptyline	Bipolar Disorder	6.59	M
11	imipramine	Mood Disorders	6.47	T
12	amitriptyline	Personality Disorders	6.21	T
13	nortriptyline	Depressive Disorder, Major	6.21	M&T
14	amitriptyline	Anxiety Disorders	5.88	T
15	amitriptyline	Sleep Disorders, Circadian Rhythm	5.82	none
16	amitriptyline	Dyssomnias	5.77	M&T
17	desipramine	Depressive Disorder	5.49	M&T
18	desipramine	Mood Disorders	5.37	M
19	amitriptyline	Schizophrenia	5.32	T
20	imipramine	Depression, Postpartum	5.23	none

CTD mark represents a drug-disease association is curated, inferred or not existed in CTD database. Curated associations include three types: marker/mechanism (CTD mark = “M”), therapeutic (CTD mark = “T”), marker/mechanism & therapeutic (CTD mark = “M&T”). If an association is inferred by CTD, CTD mark = “inferred”, and if it is not existed in CTD, CTD mark = “none”.