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. 2016 Sep 2;6(3):37. doi: 10.3390/biom6030037

Figure 1.

Figure 1

Drug screening reveals sensitivity and resistance of 35 bladder cancer cell lines to decitabine and standard chemotherapeutic agents with effects in bladder cancer. (A) Distinct 25%/50% inhibitory concentration (IC25/IC50) values for cisplatin and chemotherapy drugs are observed in the panel of 35 bladder cancer cell lines treated for 48 h with the respective agents. Cell lines are ranked (from lowest to highest, from top to bottom) on the basis of IC25/IC50 values for cisplatin. Color scale is normalized for each drug. Note that there is no correlation between resistance towards cisplatin and resistance towards decitabine (5-AZA-CdR); (B) Bladder cancer cell lines segregate into sensitive, intermediate and resistant groups according to their sensitivity to cisplatin. Sensitive cell lines: IC50 < average (IC50) − 1 SD (standard deviation); resistant cell lines: IC50 > average (IC50) + 1 SD. Experiments were run in triplicates to obtain mean IC50 values.