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. 2016 Jul 11;5(3):48. doi: 10.3390/pathogens5030048

Figure 9.

Figure 9

Production of brain cytokines and chemokines following S. suis serotype 2 infection only occurs in the presence of meningitis. Brain cytokine and chemokine levels of mock-infected (vehicle) or S. suis-infected C57BL/6 mice inoculated by intraperitoneal or intracisternal injection as determined by ELISA. Intraperitoneally injected mice were euthanized upon presentation of clinical signs of meningitis or at the end of the study (14 days post-infection) and intracisternally injected mice 24 h post-infection or at the end of the study (72 h post-infection). Brain levels of IL-1β (A); IL-6 (B); CCL2 (C); CCL3 (D); CXCL1 (E); and CXCL10 (F) following infection with EA ST1 strain P1/7, NA ST25 strain 89-1591, NA ST28 strain 1088563, or EA ST28 strain MNCM43. Data are presented as mean ± SEM pg/mL. * Indicates a significant difference with mock-infected mice (p < 0.05). EA = Eurasian; NA = North American.