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. 2016 Jul 27;6(3):25. doi: 10.3390/brainsci6030025

Figure 3.

Figure 3

Effects of restraint stress or withdrawal from chronic ethanol (WCE) on cerebro-cortical neuroimmune mRNAs. Control and stress rats received non-ethanol containing liquid diets and 1 h restraint stress or no stress, respectively. WCE rats received chronic ethanol liquid diet for 15 days followed by 29 h of withdrawal. Overall, a significant effect was also noted across the groups for CCL2 (F(2,23) = 6.47, p < 0.01) with individual comparison of groups revealing significant effects of stress or WCE relative to controls. A similar profile was noted for TNFα (F(2,32) = 10.2, p < 0.001), IL-1β (F(2,27) = 7.00, p < 0.01), and TLR4 (F(2,31) = 4.97, p < 0.05) and individual group comparisons to the respective controls. * p < 0.05, ** p < 0.01, ** p < 0.001 versus Controls. A, B, C, and D delineate data for CCL2, TNFα, IL-1β and TLR4 mRNAs, respectively, (n = 8–12 per group).