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. 2016 Jul 27;6(3):25. doi: 10.3390/brainsci6030025

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of the corticotropin-releasing factor 1 (CRF1R) antagonist CP154,526 (CP) on cerebro-cortical neuroimmune mRNAs following restraint stress in rats. Overall there was a significant effect among the groups for CCL2 (F(2,16) = 4.00, p < 0.05) with CP failing to block stressed-induction. There also was an effect of treatments for TNFα (F(2,16) = 4.87, p < 0.05) with stress inducing and CP failing to block induction. Finally, as with CCL2 and TNFα, cortical IL-1β effects were significant overall (F(2,16) = 6.34, p < 0.01), but there was no blockade of the stress effect by the drug. * p < 0.05, ** p < 0.01 versus control-vehicle treated rats. Veh = 0.5% carboxymethylcellulose. A, B, and C delineate data for CCL2, TNFα, IL-1β and TLR4 mRNAs, respectively, (n = 5–7 per group).