Table 2.
PK parameters for ODN and K11777.
| Compound | Vehicle | Dose | Cmax | Tmax | AUC0–∞ | T1/2 | F |
|---|---|---|---|---|---|---|---|
| (mg/kg) | (μM) | (h) | (μM·h) | (h) | % | ||
| ODN (rat) | 100% PEG400 | 5 | 2.2 ± 0.4 | 1.8 ± 1.5 | 36 ± 10 | 5.8 ± 0.8 | 43 ± 12 |
| ODN (dog) | 60% PEG400 | 1 | 3.6 | 8 | 318 | 64 | 122 |
| ODN (monkey) | Imwitor-Tween 80 (1:1) | 5 | 0.3 ± 0.1 | 6 ± 2.3 | 4.8 ± 1.8 | 18 ± 4.3 | 18 ± 3.8 |
| ODN (man) | capsule | 25 1 | 0.24 ± 0.052 | 14.2 ± 8.1 | 19.9 ± 4.1 | 96.7 ± 18.3 | 34 |
| K11777 (mouse) | water | 92 | 2.6 | 0.3 | 3.9 | 0.8 | n.d. |
| K11777 (rat) | water | 100 | 3.1 | 4 | 10.5 | 1.9 | 22 |
| K11777 (dog) | water | 50 | 1.4 | 0.34 | 1.0 | 0.5 | 15 |
Data for ODN are taken from [39,40] and represent means and SD values for the rat (n = 4), dog (n = 2), monkey (n = 4) and man (n = 6). In every case, a single oral dose was administered. Data for K11777 are from an internal pre-IND report from SRI International (2009). Data presented are means for the mouse (n = 3), male rat (n = 3) and dog (n = 2); n.d. = not determined; 1 Total dose (mg) administered.