Figure 1.

Molecular architecture of the Transient Receptor Potential Vanilloid 1 channel (TRPV1). Cartoon representation of the structure of the transmembrane region of TRPV1 as determined via cryoEM in lipid nanodiscs: (A) side view; and (B) top view. For clarity, only two subunits are highlighted in solid color while the other two are rendered as grey shading. Different colors highlight the major structural elements described in the text: S1–S4 domain (blue), linker domain (red), S5 (orange), pore helix and selectivity filter (yellow), S6 (brown) and TRP domain (grey).