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. 2016 Sep 20;9(3):59. doi: 10.3390/ph9030059

Table 2.

Major lipid species detected in cytoplasmic membranes of representative Gram-positive bacteria.

Organism Morphology Cell/Colony Weight Percentage of Total Lipid of Cell Membrane Major Fatty Acids References
PG lysyl-PG PI a PE CL NL Others b
Cocci round/chain
Staphylococcus aureus round/cluster 43 30 - - 22 - 5 ai-C15:0; C18:0 ai-C17:0; C20:0 [53,54]
Enterococcus faecium round/diplococci 33.8 14.4 - - 39 - 12.8 C16:0; C16:1w7c C18:1w7c [55]
Streptococcus sanguis round/diplococci 82 - - - 18 - - C18:1; C16:1; C16:0 [56,57]
Streptococcus pneumoniae round/cocci lancet shape 50 - - - 50 - - C16:0; C16:1; C18:0 [58]
Actinomycetes spherical pleomorph/filamentous
Corynebacterium glutamicum rods/V-shaped 72.4 - 13.1 - 14.1 - 0,4 C16:0; C18:1 [59,60]
Streptomyces hygroscopicus rods, mycelium - - 7 36 16 c 30 11 i-C16:0; i-C14:0; i-C15:0 [61]
Mycobacterium tuberculosis long, slender rods/filamentous - - 13 5 6 54 22 C16:1, C18:Me [62,63]
Cell wall deficient polymorph/fried egg
Mycoplasma hominis d round to oblong/fried egg 33 - - - - 60 7 C16:0; C18:0; C18:1 [64]
L-form S. aureus polymorph/fried-egg 26 17 - - 54 3 ai-C15:0; C18:0 ai-C17:0; C20:0 [53,65]
L-form S. hygroscopicus polymorph/fried-egg - - 13 37 22 16 12 ai-C15:0; ai-C17:0, i-C16:0; C18:2 e [61]
Bacilli round-ended cylinders/single or in chains
Clostridium difficile large, blunt-ended rods/pairs or chains 100 - - - - - - C16:0; C16:1 C18:0; C18:1 [66]
Bacillus subtilis Rods/chain 70 - - 12 4 - 14 ai-C15:0; i-C17:0 [67,68,69]
Listeria monocytogenes slender, short rods/single or in chains 29 23 - 9 22 - 17 ai-C15:0; i-C15:0; i-C17:0 [70]

a PI+PI mannosides; b “Others” corresponds mainly to glycolipids besides of traces of other lipids; c CL+CL derivatives; d sterol-requiring mycoplasma; e major fatty acids only in neutral lipids (NL); i, iso-branched; ai, anteiso branched fatty acids.