Table 1.
Significant regulated proteins of HT-29 cells exposed to hierridin B compared with the control group (DMSO).
| SPP | Protein Name | DMSO (Mean ± SD) | Hierridin B (Mean ± SD) | Fold (×) | Acession Number | Gene | Protein Score | Matched Peptides MS MS/MS | |
|---|---|---|---|---|---|---|---|---|---|
| 506 | Calreticulin | 3316 ± 504 | 1951 ± 172 | 0.6 | CALR_HUMAN | CALR | 215 | 15 | 2 |
| 1513 | Diablo homolog, mitochondria | 717 ± 23 | 502 ± 12 | 0.7 | DBLOH_HUMAN | DIABLO | 105 | 7 | 2 |
| 2602 | Tumor protein D52 | 946 ± 96 | 633 ± 146 | 0.7 | TPD52_HUMAN | TPD52 | 133 | 8 | 2 |
| 2713 | - | 281 ± 80 | 76 ± 70 | 0.3 | - | - | - | - | - |
| 3101 | Tubulin-specific chaperone A | 730 ± 313 | 88 ± 18 | 0.1 | TBCA_HUMAN | TBCA | 130 | 6 | 3 |
| 3113 | - | 1504 ± 226 | 148 ± 142 | 0.1 | - | - | - | - | - |
| 3304 | Stathmin | 700 ± 179 | 95 ± 67 | 0.1 | STMN1_HUMAN | STMN1 | 85 | 5 | 1 |
| 3507 | - | 2247 ± 768 | 6225 ± 2081 | 2.8 | - | - | - | - | - |
| 3514 | UMP-CMP kinase | 721 ± 148 | 240 ± 243 | 0.3 | KCY_HUMAN | CMPK1 | 100 | 5 | 2 |
| 4704 | Serum albumin | 6705 ± 611 | 3282 ± 1123 | 0.5 | ALBU_HUMAN | ALB | 74 | 4 | 1 |
| 4802 | Gelsolin | 743 ± 239 | 355 ± 192 | 0.5 | GELS_HUMAN | GSN | 178 | 17 | 2 |
| 4901 | Neutral alpha-glucosidase AB | 577 ± 178 | 153 ± 69 | 0.3 | GANAB_HUMAN | GANAB | 304 | 23 | 3 |
| 5601 | Heat-shock protein beta-1 | 680 ± 70 | 517 ± 75 | 0.8 | HSPB1_HUMAN | HSPB1 | 128 | 3 | 1 |
| 5801 | Delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, mitochondrial | 980 ± 40 | 1368 ± 230 | 1.4 | ECH1_HUMAN | ECH1 | 200 | 10 | 3 |
| 6105 | Ubiquitin-like protein ISG15 | 2519 ± 237 | 884 ± 473 | 0.4 | ISG15_HUMAN | ISG15 | 80 | 4 | 1 |
| 6202 | Alpha-enolase | 9861 ± 410 | 7341 ± 1801 | 0.7 | ENOA_HUMAN | ENO1 | 499 | 23 | 3 |
| 7112 | - | 1293 ± 155 | 232 ± 131 | 0.2 | - | - | - | - | - |
| 7305 | Serine hydroxymethyl transferase, mitochondrial | 718 ± 113 | 308 ± 93 | 0.4 | GLYM_HUMAN | SHMT2 | 277 | 17 | 2 |
| 7803 | Elongation factor 2 | 511 ± 90 | 181 ± 92 | 0.4 | EF2_HUMAN | EEF2 | 304 | 22 | 3 |
| 7804 | Elongation factor 2 | 811 ± 236 | 405 ± 128 | 0.5 | EF2_HUMAN | EEF2 | 307 | 26 | 3 |
| 8404 | t-complex protein 1 subunit delta | 543 ± 163 | 272 ± 112 | 0.5 | TCPD_HUMAN | CCT4 | 158 | 12 | 3 |
| 8802 | Voltage-dependent anion-selective channel protein 1 | 2319 ± 695 | 3487 ± 162 | 1.5 | VDAC1_HUMAN | VDAC1 | 111 | 8 | 1 |