Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Sep 2;14(9):160. doi: 10.3390/md14090160

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

11-Dehydrosinulariolide reduced apoptosis after SCI. The rats were sacrificed 8 h after SCI, and their spinal cords were harvested. The apoptotic cells were identified through a TUNEL assay (A); Cells with the TUNEL signal (green), which colocalized with DAPI (blue), were counted as apoptotic. 11-Dehydrosinulariolide significantly reduced the number of apoptotic cells after SCI. 11-Dehydrosinulariolide administration attenuated SCI-induced Bcl-2 downregulation (B); The neuronal Bcl-2 IR signal in the 11-dehydrosinulariolide group was stronger than that in the SCI group. Data are expressed as means ± SEMs; # p < 0.05 and ## p < 0.001 compared with the control group; * p < 0.05 and ** p < 0.001 compared with the vehicle group. Scale bars = 100 μm in (A), 50 μm in (B).