Table 1.

Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2).

Study	Risk of Bias				Applicability Concerns
	Patient Selection	Index Test	Reference Standard	Flow and Timing	Patient Selection	Index Test	Reference Standard
D’Assignies et al. 2008 [18]	$☺$	$☹$	$☺$	$☺$	$☺$	$☺$	$☺$
Delrue et al. 2011 [19]	$☹$	$☹$	$☺$	$☺$	$☺$	$☺$	$☺$
Delrue et al. 2011 [20]	$☺$	$☺$	$☹$	$?$	$☹$	$☺$	$☺$
D’Onofrio et al. 2012 [21]	$☺$	$☹$	$☺$	$☺$	$☺$	$☺$	$☺$
Kandel et al. 2009 [22]	$☺$	$☹$	$☺$	$☺$	$☺$	$☺$	$☺$
Klauss et al. 2012 [23]	$☺$	$☹$	$☺$	$☺$	$☺$	$☺$	$☺$
Lu et al. 2011 [24]	$☹$	$☹$	$☺$	$☺$	$☺$	$☺$	$☺$
Nishikawa et al. 2014 [25]	$☹$	$☹$	$☺$	$☺$	$☺$	$☺$	$☺$
Xu et al. 2009 [26]	$☹$	$☹$	$☺$	$☺$	$☺$	$☺$	$☺$
Park et al. 2009 [27]	$☺$	$☹$	$☺$	$☺$	$☺$	$☺$	$☺$
Klauss et al. 2012 [28]	$☺$	$☹$	$☺$	$☺$	$☺$	$☺$	$☺$
Li et al. 2013 [29]	$☹$	$☹$	$☺$	$☹$	$☺$	$☺$	$☺$
Tan et al. 2015 [30]	$☺$	$☹$	$☺$	$☺$	$☺$	$☺$	$☺$

Risk of bias and concerns regarding applicability of the included studies: $☺$ Low Risk; $☹$ High Risk; $?$ Unclear Risk.