Figure 6.

Nrf2-activators dose-dependently increase HO-1 protein expression in primary rat OPCs. After 2 day de-differentiation of OLs with growth factors bFGF-2 and PDGF-AA, primary rat OPCs were treated with 5 µM SFN, 90 µM MMF,30 µg/mL Protandim or their respective DMSO or EtOH vehicle control for 24 h. Protein levels were assayed by Western blotting. Data are presented as percentage of control and expressed as the mean ± SEM of 3 independent experiments. Statistics reflect one-way ANOVA test with post hoc Bonferroni correction; * p < 0.05.